480424-94-0

Basic information

• Product Name: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE
• Synonyms: 4-FORMYLAMINOPHENYLBORONIC ACID, PINACOL ESTER;N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE;4-formamidophenylboronic acid pinacol ester;4-Formamidophenylboronic acid pinacol ester, N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]formamide
• CAS NO: 480424-94-0
• Molecular Formula: C13H18BNO3
• Molecular Weight: 247.1
• EINECS: 941-095-7
• Product Categories: Heterocyclic Compounds
• Mol File: 480424-94-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 116.7-118.2°C
• Boiling Point: 403.6 °C at 760 mmHg
• Flash Point: 197.9 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 1E-06mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: 2-8°C
• PKA: 15.13±0.70(Predicted)
• CAS DataBase Reference: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE(480424-94-0)
• EPA Substance Registry System: N-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]FORMAMIDE(480424-94-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 480424-94-0(Hazardous Substances Data)

Usage

Uses

4-Formamidophenylboronic acid, pinacol ester

InChI:InChI=1/C13H18BNO3/c1-12(2)13(3,4)18-14(17-12)10-5-7-11(8-6-10)15-9-16/h5-9H,1-4H3,(H,15,16)

Upstream product

• 50978-45-5 3-oxobenzo[d]isothiazole-2(3H)-carbaldehyde 1,1-dioxide 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 109-94-4 formic acid ethyl ester 
• 64-18-6 formic acid 
• 141-53-7 sodium formate 

Relevant articles and documents

Synthesis and stability study of isocyano aryl boronate esters and their synthetic applications

A facile synthesis of isocyano arylboronate esters is reported. Although tri-coordinate boron functional groups are commonly recognized as vulnerable to nucleophilic attack, the newly reported tri-coordinate isocyano arylboronate esters were found to be stable, albeit owing to the presence of an isocyano group. Theoretical calculations, using the DFT/B3LYP/6-31G(d,p) method, revealed that the electron delocalization between the aryl group and the boron atom might contribute to this stability. UV-vis spectroscopic investigations on 2-(4-isocyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (2a) were in agreement with the theoretical studies, showing a red-shifted absorption compared with that of phenylisonitrile. The reported strategy allows boronate ester substrates to survive throughout two-step operations. Two of the compounds synthesized were successfully exploited in Ugi and Passerini multicomponent reactions to afford corresponding products. In addition, two boron-containing tetrazoles were also prepared under environmentally benign conditions. These results demonstrated that functionalized isocyanides are stable and can be used as strategically as synthetic building blocks.

NOVEL BIPHENYL COMPOUNDS AND THEIR USE

The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereo