4782-69-8

Basic information

• Product Name: 1-(2-NAPHTHYL)-3-PHENYLPROP-2-EN-1-ONE
• Synonyms: 1-(2-NAPHTHYL)-3-PHENYLPROP-2-EN-1-ONE
• CAS NO: 4782-69-8
• Molecular Formula: C₁₉H₁₄O
• Molecular Weight: 258.31
• Mol File: 4782-69-8.mol
• Article Data: 71

Chemical Properties

• Boiling Point: 441.1°C at 760 mmHg
• Flash Point: 195.4°C
• Appearance: /
• Density: 1.153g/cm³
• Vapor Pressure: 5.57E-08mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 1-(2-NAPHTHYL)-3-PHENYLPROP-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-NAPHTHYL)-3-PHENYLPROP-2-EN-1-ONE(4782-69-8)
• EPA Substance Registry System: 1-(2-NAPHTHYL)-3-PHENYLPROP-2-EN-1-ONE(4782-69-8)

Safety Data

• Hazardous Substances Data: 4782-69-8(Hazardous Substances Data)

Usage

General Description

1-(2-Naphthyl)-3-phenylprop-2-en-1-one, also known as 2'-Naphthylchalcone, is a chemical compound with the molecular formula C18H14O. It is a chalcone derivative with a complex chemical structure, containing a naphthalene ring and a phenyl ring connected by a propenone group. 1-(2-NAPHTHYL)-3-PHENYLPROP-2-EN-1-ONE has been studied for its potential biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It is also used in organic synthesis as a precursor for the production of various pharmaceuticals and natural products. Additionally, 1-(2-Naphthyl)-3-phenylprop-2-en-1-one has been investigated for its potential applications in the development of new materials and as a fluorescent dye.

InChI:InChI=1/C19H14O/c20-19(13-10-15-6-2-1-3-7-15)18-12-11-16-8-4-5-9-17(16)14-18/h1-14H/b13-10+

Upstream product

• 7228-47-9 2-(2-naphthyl)ethanol 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 93-08-3 methyl 2-naphthyl ketone 
• 478282-11-0 1-(2-naphthyl)-3-phenyl-prop-2-yn-1-ol 
• 66-99-9 β-naphthaldehyde 
• 536-74-3 phenylacetylene 
• 4842-47-1 1‐(2‐naphthyl)‐3‐phenylpropan‐1‐one 
• 140-10-3 (E)-3-phenylacrylic acid 
• 14289-45-3 2-(naphthalen-2-yl)-2-oxoacetic acid 
• 621-82-9 Cinnamic acid 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 6783-05-7 trans-2-phenylvinylboronic acid 

Downstream Products

• 4842-47-1 1‐(2‐naphthyl)‐3‐phenylpropan‐1‐one 
• 56345-32-5 (E)-1-(naphthalen-2-yl)-3-phenylprop-2-en-1-ol 
• 722459-38-3 naphthalen-2-yl(4-phenyl-1H-pyrrol-3-yl)methanone 
• 60857-46-7 trans‐2,3‐epoxy‐1‐(naphthalen‐2‐yl)‐3‐phenylpropan‐1‐one 
• 60857-46-7 (naphthalen-2-yl)(3-phenyloxiran-2-yl)methanone 
• 1026166-45-9 4-(3-Naphthalen-2-yl-3-oxo-1-phenyl-propyl)-3,4-dihydro-1H-benzo[b]azepine-2,5-dione 
• 908073-36-9 2-Naphthalen-2-yl-4-phenyl-5,7-dihydro-1,7-diaza-dibenzo[a,c]cyclohepten-6-one 
• 31638-57-0 2,3-Dibromo-1-naphthalen-2-yl-3-phenyl-propan-1-one 
• 1268449-23-5 (2R,3S)-tert-butyl 2-((diphenylmethylene)amino)-5-oxo-3-phenyl-5-(2’-naphtyl)pentanoate 
• 1338349-87-3 1-(naphthalen-2-yl)-3-phenyl-3-phenylsulfanylpropan-1-one 
• 2256-23-7 3-(naphthalen-2-yl)-1,5-diphenyl-4,5-dihydro-1H-pyrazole 
• 1246732-25-1 (S)-1-(naphthalen-2-yl)-3-phenylpentan-1-one 

Relevant articles and documents

Potassium Base-Promoted Diastereoselective Synthesis of 1,3-Diols from Allylic Alcohols and Aldehydes through a Tandem Allylic-Isomerization/Aldol–Tishchenko Reaction

This study reports the first base-promoted aldol–Tishchenko reactions of allylic alcohols with aldehydes initiated by allylic isomerization. The reaction enables the diastereoselective synthesis of a variety of 1,3-diols with three contiguous stereogenic centers. Unlike commonly reported systems, our method allows the use of readily available allylic alcohols as nucleophiles instead of enolizable aldehydes and ketones.

Ag2CO3-catalyzed efficient synthesis of internal or terminal propargylicamines and chalcones via A3-coupling under solvent-free condition

Several simple, fast and practical protocols have been developed to synthesize internal or terminal propargylamines and chalcones via A3-coupling reaction of aldehydes, amines, and alkynes catalyzed by an easily available catalyst Ag2CO3 under solvent-free condition. The reaction proceeded smoothly to deliver various products in good-to-excellent yields with good functional group tolerance. Gram-scale preparation, bioactive molecule synthesis and asymmetric substrates have been demonstrated. Furthermore, plausible mechanisms for the synthesis of different products have been proposed.

N-Heterocyclic Carbene Catalyzed Synthesis of Trisubstituted Epoxides via Tandem Amidation/Epoxidation Sequence

A tandem amidation/epoxidation sequence between various substituted chalcones and N,N-dimethylformamide (DMF) for the synthesis of trisubstituted epoxides employing N-heterocyclic carbene catalysis was developed. This reaction was performed under metal-free conditions in the presence of tert-butyl hydroperoxide (TBHP) as the oxidant. Trisubstituted epoxides bearing a ketone and an amide functionality (N,N-dimethyl formyl group) were synthesized starting from a wide range of chalcones in moderate to good yields with excellent diastereoselectivity.