477-85-0

Basic information

• Product Name: Obtusifolin
• Synonyms: Obtusifolin;2,8-Dihydroxy-1-methoxy-3-methyl-9,10-anthracenedione;9,10-Anthracenedione, 2,8-dihydroxy-1-methoxy-3-methyl-;Anthraquinone, 2,8-dihydroxy-1-methoxy-3-methyl-;Obtusifolin (anthraquinone);2,8-Dihydroxy-1-Methoxy-3-Methylanthraquinone
• CAS NO: 477-85-0
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26348
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 477-85-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 242-243℃
• Boiling Point: 528°Cat760mmHg
• Flash Point: 202.1°C
• Appearance: /
• Density: 1.448±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 9.12E-12mmHg at 25°C
• Refractive Index: 1.677
• PKA: 6.60±0.20(Predicted)
• CAS DataBase Reference: Obtusifolin(CAS DataBase Reference)
• NIST Chemistry Reference: Obtusifolin(477-85-0)
• EPA Substance Registry System: Obtusifolin(477-85-0)

Safety Data

• Hazardous Substances Data: 477-85-0(Hazardous Substances Data)

Usage

Description

Obtusifolin is a primary reference substance with assigned absolute purity, taking into account chromatographic purity, water, residual solvents, and inorganic impurities. It is produced by PhytoLab GmbH & Co. KG and is used for various applications across different industries.

Uses

Used in Pharmaceutical Industry:
Obtusifolin is used as a pharmaceutical agent for its potential therapeutic properties. It is valued for its ability to modulate various biological pathways and exhibit inhibitory effects on certain conditions, making it a promising candidate for drug development and treatment of specific diseases.
Used in Research and Development:
In the research and development sector, Obtusifolin serves as a crucial reference substance. Its assigned absolute purity makes it an essential tool for scientists and researchers to conduct experiments and develop new drugs or therapies with a high level of accuracy and reliability.
Used in Quality Control and Standardization:
Obtusifolin is utilized in quality control processes to ensure the consistency and standardization of products in the pharmaceutical and related industries. Its assigned purity value helps in maintaining the quality of drugs and other products by providing a benchmark for comparison and assessment.
Used in Drug Delivery Systems:
Similar to gallotannin, Obtusifolin can also be employed in the development of novel drug delivery systems. These systems aim to enhance the delivery, bioavailability, and therapeutic outcomes of the substance by using various organic and metallic nanoparticles as carriers.

InChI:InChI=1/C16H12O5/c1-7-6-9-12(16(21-2)13(7)18)15(20)11-8(14(9)19)4-3-5-10(11)17/h3-6,17-18H,1-2H3

Upstream product

• 127042-39-1 (3R,4S,4aS,9aR)-4a,9a-Dichloro-8-hydroxy-4-methoxy-3-methyl-3,4,4a,9a-tetrahydro-1H-anthracene-2,9,10-trione 
• 108637-73-6 (E)-1-Methoxy-3-methyl-1,2-bis-trimethylsilanyloxy-buta-1,3-diene 
• 127042-37-9 (3R,4S,4aS,9aR)-4a,9a-Dichloro-4,8-dimethoxy-3-methyl-3,4,4a,9a-tetrahydro-1H-anthracene-2,9,10-trione 
• 72476-03-0 (E)-3-methyl-4-methoxy-2-[(trimethylsilyl)oxy]-1,3-butadiene 
• 71700-71-5 2,3-dichloro-5-methoxy-1,4-naphthoquinone 
• 108637-71-4 Methyl 3-methyl-2-trimethylsiloxy-2-butenoate 
• 108637-81-6 (1R,4aS,9aR)-9a-Chloro-8-hydroxy-1-methoxy-3-methyl-1,2-bis-trimethylsilanyloxy-1,4,4a,9a-tetrahydro-anthraquinone 
• 108637-77-0 (1S,4aR,9aS)-8-Hydroxy-1-methoxy-3-methyl-1,2-bis-trimethylsilanyloxy-1,4,4a,9a-tetrahydro-anthraquinone 
• 481-39-0 5-hydroxynaphtho-1,4-quinone 
• 108637-73-6 1-Methoxy-3-methyl-1,2-bis(trimethylsiloxy)-1,3-butadiene 

Downstream Products

• 58322-78-4 2-hydroxychrysophanol 
• 38393-67-8 Hallachrome 

Relevant articles and documents

Acetylated anthraquinone glycosides from Cassia obtusifolia

Three new acetylated anthraquinone glycosides (1-3) were isolated from the seed of Cassia obtusifolia, together with one parent anthraquinone glycoside (1a). Their structures were determined on the basis of spectroscopic methods and physicochemical properties as obtusifoline-2-O-β-d-2, 6-di-O- acetylglucopyranoside (1), obtusifoline-2-O-β-d-glucopyranoside (1a), obtusifoline-2-O-β-d-3, 6-di-O-acetylglucopyranoside (2), and obtusifoline-2-O-β-d-4, 6-di-O-acetylglucopyranoside (3).

DICHLORO QUINONES AS DIENOPHILES; SYNTHESIS OF ALIZARIN DERIVATIVES

2,3-Dichloro quinonoid dienophiles react with 1,3-dioxy butadienes to give cycloadducts, which aromatise with uptake of external nucleophile to give 1,2-disubstitution in the newly formed aromatic ring.With oxy nucleophiles this has led to synthesis of natural alizarin derivatives.