4747-13-1Relevant articles and documents
New Surprises with Fischer Carbene Complexes: Formal [3 + 2] Cycloadditions with and without Preceding Carbene-Ligand Metathesis
Hoffmann, Matthias,Buchert, Matthias,Reissig, Hans-Ulrich
, p. 283 - 285 (1997)
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Ketal derivative of drug and preparation method thereof, pharmaceutical composition and application
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Paragraph 0139-0141, (2021/02/10)
The invention relates to a ketal derivative of a drug, and a preparation method thereof, a pharmaceutical composition and application. The ketal derivative comprises a compound as shown in a formula (I) (See the specification), a racemate, a stereoisomer, a tautomer or pharmaceutically acceptable salts thereof. The ketal derivative provided by the invention can significantly improve the physical,chemical and/or pharmaceutical properties of an original starting drug.
Synthesis of acid-sensitive connection unit and its use in DNA sequencing
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Paragraph 0263-0267, (2018/02/04)
The invention discloses a synthesis method of an acid sensitive connection unit, and a use of the acid sensitive connection unit in DNA sequencing. The structural formula of the acid sensitive connection unit is shown in the specification. In the structural formula, R is NH2 or N3, m is an integer from 0 to 44, and n is an integer from 0 to 44; R1 and R2 respectively represent an aliphatic alkyl group, or R1 and R2 respectively represent an aromatic derivative, or R1 is a phenyl group, a naphthyl group, a phenyl derivative or a naphthyl derivative, and R2 is an aliphatic alkyl group or hydrogen; or R2 is a phenyl group, naphthyl group, a phenyl derivative or a naphthyl derivative, R1 is an aliphatic alkyl group or hydrogen, or R1 and R2 form a cyclohexyl group, a cyclopentyl group or a cyclobutyl group. A reversible terminal obtained through connecting the acid sensitive connection unit with nucleotide and fluorescein can be used in DNA sequencing-by-synthesis. The reversible terminal can be used in the DNA sequencing; and raw materials required by the synthesis method are simple and can be easily obtained, and the synthesis process is a routine chemical reaction, so the method can realize large scale popularization use.