4741-99-5Relevant articles and documents
Polyamines XIV. Protonation Equilibria of Linear Tetraamines Containing two Ethylenediamine Residues
Anderegg, Giorgio,Blaeuenstein, Peter
, p. 162 - 169 (1982)
The syntheses of the linear tetraamines H2N-(CH2)2-NH-(CH2)n-NH-(CH2)2-NH2 (n = 4 and 5) are described.The protonation of the homologous tetraamines for n = 2, 3, 4, 5, 6 and 8, as well as of N-methylethylenediamine, was investigated using potentiometric and calorimetric measurements.The results obtained are discussed taking into consideration the substituent effect on the basicity of the aminic N-atoms.
Composition, synthesis and therapeutic applications of polyamines
-
, (2008/06/13)
This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicty of neutoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan. These polyamines can be to treat neurological, cardiovascular, endocrine acquired and inherited mitochondrial DNA damage diseases and other disorders in mammalian subjects, and more specifically to the therapy of Parkinson's disease, Alzheimer's disease, Lou Gehrig's disease, Binswanger's disease, Olivopontine Cerebellar Degeneration, Lewy Body disease, Diabetes, Stroke, Atherosclerosis, Myocardial Ischemia, Cardiomyopathy, Nephropathy, Ischemia, Glaucoma, Presbycussis, Cancer, Osteoporosis, Rheumatoid Arthritis, Inflammatory Bowel Disease, Multiple Sclerosis and as Antidotes to Toxin Exposure.
Valency platform molecules comprising aminooxy groups
-
, (2008/06/13)
Molecules comprising aminooxy groups are provided, wherein the aminooxy groups provide attachment sites for the covalent attachment of other molecules. In one embodiment, polyoxyethylene molecules comprising aminooxy groups are provided that can be conjugated to wide variety of biologically active molecules including poly(amino acids). In another embodiment, valency platform molecules comprising aminooxy groups are provided. The aminooxy groups can be used to form covalent bonds with biological molecules such as poly(amino acids). The aminooxy groups can, for example, react with poly(amino acids) modified to contain carbonyl groups, such as glyoxyl groups, to form a conjugate of the valency platform molecule and the biologically active molecule via an oxime bond. The valency platform molecules comprising aminooxy groups are advantageously reactive in the formation of conjugates, and they also can be readily synthesized to form a composition with very low polydispersity.
Composition, synthesis and therapeutic applications of polyamines
-
, (2008/06/13)
The invention relates to the preparation of novel polyamines, such as derivatives of 1,3-bis-[(2′-aminoethyl)-amino]propane (2,3,2-tetramine) and 1,4,8,11-tetraazacyclotetradecane (cyclam), which can be used to treat mitochondrial and degenerative diseases. Accordingly, in one aspect the invention is directed to compounds of the formula: wherein R1, R2, R3, R4, R5 and R6 may be the same or different and are hydrogen, alkyl, aryl, cycloalkyl, amino acid, glutathione, urate, ascorbate, estrogen, dehydroepiandrosterone, redox stabilizing substituents, a quinone, glutamate, succinate, —(CH2)n[XCH2)n]NH2— wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon, or heterocycle wherein R1 to R6 taken together are —(CH2XCH2)n— wherein n=3-6 and X=nitrogen, sulfur, phosporous or carbon. M, n, and p may be the same or different and are bridging groups of variable length from 3-12 carbons. X1 and X2 may be the same or different and are nitrogen, sulfur, phosporous or carbon.