4706-43-8Relevant articles and documents
Scalable Synthesis of Benzotriazoles via [3+2] Cycloaddition of Azides and Arynes in Flow
Kleoff, Merlin,Boeser, Lisa,Baranyi, Linda,Heretsch, Philipp
supporting information, p. 979 - 982 (2021/01/18)
A method for the metal-free synthesis of benzotriazoles in flow is reported. Using azides and in situ generated arynes, benzotriazoles are formed in a [3+2] cycloaddition within minutes. Employing different substitution patterns of the azide and aryne coupling partners, a modular access to benzotriazoles is provided. Thermal strain of hazardous azides and accumulation of reactive intermediates is minimized by short reaction times in flow, improving the safety profile of the process. The scalability of the reaction is demonstrated.
Facile one-pot synthesis of diarylacetylenes from arylaldehydes: Via an addition-double elimination process
Chen, Jianyang,Zhang, Xuan,Wu, Jiajun,Wang, Rui,Lei, Chunlin,An, Yanan
supporting information, p. 4701 - 4705 (2021/06/11)
A practical one-pot protocol has been developed to synthesize diarylacetylenes from arylaldehydes by treatment with 1-(arylmethyl)benzotriazoles and LiN(SiMe3)2. The reaction proceeded through imine formation, Mannich-type addition and double elimination to deliver products in up to 99% yields with broad substrate scope. In addition, gram-scale synthesis of 1-bromo-4-(phenylethynyl)benzene has been demonstrated.
Synthesis, characterization, and antimicrobial activity of lipophilic N,N′-bis-substituted triazolium salts
Fico, Dominic,Gorden, John D.,Johnson, Shanina S.,King, Lauren B.,Lin, Zi Jie,Martz, Luke,Rodriguez, Isabelle,Shelton, Kerri L.,Ta, Thong,Wilson, Julie A.
supporting information, (2021/11/30)
A series of N,N′-bis-substituted triazolium salts have been synthesized using 1H-1,2,4-triazole, 1H-1,2,3-triazole, and 1H-1,2,3-benzotriazole. Synthesized compounds were tested for their antimicrobial activities against a panel of representative ESKAPE p