452-78-8

Basic information

• Product Name: 3-FLUORO-4-METHYLPHENOL
• Synonyms: 2-Fluoro-4-hydroxytoluene;3-FLUORO-4-METHYLPHENOL;3-FLUORO-P-CRESOL;3-Fluoro-p-cresol (OH=1);3-Fluoro-4-methylphenol, JRD,
• CAS NO: 452-78-8
• Molecular Formula: C₇H₇FO
• Molecular Weight: 126.13
• EINECS: 200-110-4
• Product Categories: NULL;Fluorine series;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Fluorine Compounds;Phenols
• Mol File: 452-78-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 72 °C
• Boiling Point: 196 °C
• Flash Point: 29 °C
• Appearance: /
• Density: 1.17
• Vapor Pressure: 0.32mmHg at 25°C
• Refractive Index: 1.5150
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.27±0.18(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-METHYLPHENOL(452-78-8)
• EPA Substance Registry System: 3-FLUORO-4-METHYLPHENOL(452-78-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 21/22-34-52-36-22
• Safety Statements: 26-36/37/39-60-45
• RIDADR: 2922
• HazardClass: 8
• Hazardous Substances Data: 452-78-8(Hazardous Substances Data)

Usage

Description

3-FLUORO-4-METHYLPHENOL is a phenolic derivative characterized by the presence of a fluorine atom at the 3-position and a methyl group at the 4-position on a phenol molecule. This unique structure endows it with specific chemical properties that make it a valuable compound in various applications.

Uses

Used in Pharmaceutical Industry:
3-FLUORO-4-METHYLPHENOL is used as a pharmaceutical intermediate for the synthesis of various drugs and pharmaceutical compounds. Its unique structure allows it to serve as a building block in the development of new medications, potentially leading to the creation of novel therapeutic agents with improved efficacy and selectivity.
Used in Chemical Synthesis:
3-FLUORO-4-METHYLPHENOL can also be utilized in the synthesis of various organic compounds, including agrochemicals, dyes, and other specialty chemicals. Its reactivity and functional groups make it a versatile intermediate in the chemical industry, contributing to the development of new products and technologies.

Physical state

3-FLUORO-4-METHYLPHENOL is solid.

InChI:InChI=1/C7H7FO/c1-5-2-3-6(9)4-7(5)8/h2-4,9H,1H3

Upstream product

• 405-06-1 2-fluoro-4-methoxy-1-methylbenzene 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 452-77-7 3-fluoro-4-methyl-phenylamine 

Downstream Products

• 83341-28-0 5-fluoro-4-methyl-2-nitrophenol 
• 83341-37-1 2-amino-5-fluoro-4-methylphenol 
• 331746-01-1 3-fluoro-4-methylphenyl carbonochloridate 
• 405-06-1 2-fluoro-4-methoxy-1-methylbenzene 
• 903895-56-7 2-(3-fluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1072003-29-2 tert-butyl [2-amino-5-(3-fluoro-4-methylphenoxy)phenyl]methylcarbamate 
• 1072002-07-3 3-{[6-(3-fluoro-4-methylphenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid 
• 1072003-32-7 methyl 3-{[6-(3-fluoro-4-methylphenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoate 
• 1072003-31-6 [6-(3-fluoro-4-methylphenoxy)-1-methyl-1H-benzimidazol-2-yl]methanol 
• 1072004-54-6 6-(3-fluoro-4-methylphenoxy)-N₂-methylpyridine-2,3-diamine 

Relevant articles and documents

NOVEL CHROMEN-2-ONE BASED HYDROXAMIC ACID DERIVATIVES HAVING ANTI-INFLAMMATORY ACTIVITY, THE PREPARATION THEREOF AND A COMPOSITION CONTAINING THE SAME FOR TREATING INFLAMMATORY DISEASE

The present invention relates to novel chromen-2-one based hydroxamic acid derivatives having anti-inflammatory activity, the preparation thereof and a composition containing the same for treating inflammatory disease.

Substituted acid derivatives useful as antidiabetic and antiobesity agents and method

Compounds are provided which have the structure wherein Q is C or N, A is 0 or S, Z is O or a bond, X is CH or N and R1, R2, R2a, R2b, R2c, R3, Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.