450-91-9

Basic information

• Product Name: 4-FLUORO-2-METHOXYANILINE
• Synonyms: 4-FLUORO-2-METHOXYANILINE;2-Methoxy-4-fluoroaniline;4-Fluoro-o-anisidine, 2-Amino-5-fluoroanisole;2-AMino-5-fluoroanisole[4-Fluoro-2-Methoxyaniline];4-Fluoro-2-MethoxybenzenaMine;o-Anisidine, 4-fluoro-;4-Fluoro-2-methoxy-phenylamine;2-Amino-5-fluoroanisole
• CAS NO: 450-91-9
• Molecular Formula: C₇H₈FNO
• Molecular Weight: 141.15
• EINECS: 1592732-453-0
• Mol File: 450-91-9.mol
• Article Data: 39

Chemical Properties

• Boiling Point: 215℃ (756 Torr)
• Flash Point: 79.5±21.8℃
• Appearance: /Solid
• Density: 1.176±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.22mmHg at 25°C
• Refractive Index: 1.5400 to 1.5440
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.60±0.10(Predicted)
• CAS DataBase Reference: 4-FLUORO-2-METHOXYANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-2-METHOXYANILINE(450-91-9)
• EPA Substance Registry System: 4-FLUORO-2-METHOXYANILINE(450-91-9)

Safety Data

• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 450-91-9(Hazardous Substances Data)

Usage

Description

4-Fluoro-2-methoxyaniline is an organic compound that serves as a valuable synthetic intermediate in the chemical and pharmaceutical industries. It is characterized by its fluorine and methoxy substituents on the aniline structure, which contribute to its reactivity and utility in various chemical reactions.

Uses

Used in Pharmaceutical Industry:
4-Fluoro-2-methoxyaniline is used as a synthetic intermediate for the preparation of ortho-substituted phenylureas, which are known as 5-Hydroxytryptamine (5-HT3) receptor antagonists. These antagonists play a crucial role in treating various conditions, such as nausea, vomiting, and migraines, by blocking the action of serotonin on the 5-HT3 receptors.
Additionally, 4-Fluoro-2-methoxyaniline is utilized in the synthesis of hydroxamic acids and their prodrugs. These compounds act as inhibitors for the Botulinum neurotoxin A light chain, which is a significant concern in the development of therapeutics against botulism, a severe and potentially fatal form of food poisoning.

Physical Form

Yellow to Orange to Brown Solid or liquid

InChI:InChI=1/C7H8FNO/c1-10-7-4-5(8)2-3-6(7)9/h2-4H,9H2,1H3

Upstream product

• 456-49-5 1-fluoro-3-methoxybenzene 
• 446-35-5 2,4-Difluoronitrobenzene 
• 82344-33-0 N-hydroxy-N-(2-methoxyphenyl)acetamide 
• 582-11-6 N-(4-fluoro-2-methoxyphenyl)acetamide 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 7440-02-0 nickel 
• 446-36-6 5-fluoro-2-nitrophenol 

Downstream Products

• 450-89-5 1-chloro-4-fluoro-2-methoxybenzene 
• 450-88-4 1-bromo-4-fluoro-2-methoxybenzene 
• 450-90-8 4-fluoro-1-iodo-2-methoxybenzene 
• 450-84-0 5-fluoro-2-nitroso-anisole 
• 582-11-6 N-(4-fluoro-2-methoxyphenyl)acetamide 
• 102392-13-2 3-[4-(4-Fluoro-2-methoxy-phenyl)-piperazin-1-yl]-propylamine 
• 102392-12-1 N-[3-[4-(4-fluoro-2-methoxyphenyl)-1-piperazinyl]propyl]-phthalimide 
• 193975-16-5 8-Cyano-4-{3-[4-(4-fluoro-2-methoxy-phenyl)-piperazin-1-yl]-propylamino}-quinoline-3-carboxylic acid dimethylamide 
• 1545025-47-5 2-amino-5-fluoro-3-methoxybenzonitrile 
• 1591828-99-7 2-bromo-5-fluoro-3-methoxybenzonitrile 
• 1591829-01-4 5-fluoro-3-methoxy-2-methylbenzonitrile 
• 1591829-03-6 5-fluoro-3-hydroxy-2-methylbenzonitrile 
• 1591826-68-4 5-fluoro-2-methyl-3-(6-oxo-1-((6-oxo-1,6-dihydropyridazin-3-yl)methyl)-4-(trifluoro methyl)-1,6-dihydropyrimidin-5-yloxy)benzonitrile 

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