4499-40-5 Usage
Description
CHOLINE THIEOPHYLLINATE, also known as Oxytiphylline, is a xanthine alkaloid derivative used in the pharmaceutical industry. It is a bronchodilator that helps to relax and widen the airways, making it easier to breathe. It is commonly used in the treatment of respiratory conditions such as chronic asthma and other obstructive pulmonary diseases.
Uses
Used in Pharmaceutical Industry:
CHOLINE THIEOPHYLLINATE is used as a bronchodilator for the treatment of respiratory conditions such as chronic asthma and other obstructive pulmonary diseases. It works by relaxing and widening the airways, making it easier for patients to breathe.
Used in Chronic Asthma Treatment:
CHOLINE THIEOPHYLLINATE is used as a therapeutic agent for the treatment of chronic asthma. It helps to alleviate symptoms such as wheezing, shortness of breath, and coughing by improving lung function and reducing inflammation.
Brand Name:
One of the brand names for CHOLINE THIEOPHYLLINATE is Choledyl, which is manufactured by Parke-Davis. This brand is specifically formulated to provide relief from the symptoms of chronic asthma and other respiratory conditions.
Originator
Sabidal ,S.R. Zyma, UK ,1983
Manufacturing Process
18 parts by weight of theophylline are added to 37.8 parts by weight of
aqueous choline bicarbonate (47% assay) and the mixture stirred and heated
at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete
solution effected. Water is separated from the reaction mixture by distillation
under a vacuum sufficient to keep the still temperature between 50°C and 55
C. After about 95 parts by weight of water have been separated, about 80
parts by weight of isopropyl alcohol are added and the mixture subjected to
further distillation under a vacuum sufficient to keep the mixture boiling at
about 40°C. The distillation removes some of the water as an azeotrope with
the isopropyl alcohol. During the removal of the water-isopropyl alcohol
azeotrope a crystalline precipitate forms. The mixture is further cooled slowly
to 5°C and the crystalline precipitate filtered off. The choline theophyllinate
crystals are then washed with isopropyl alcohol and dried under vacuum at
about 70°C. A second crop of the product may be obtained from the mother
liquor by further reduction in volume and cooling. A yield of 90.5% of theory
of choline theophyllinate is obtained completely free of inorganic salts.
Therapeutic Function
Smooth muscle relaxant
Check Digit Verification of cas no
The CAS Registry Mumber 4499-40-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,9 and 9 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4499-40:
(6*4)+(5*4)+(4*9)+(3*9)+(2*4)+(1*0)=115
115 % 10 = 5
So 4499-40-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N4O2.C5H14NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-6(2,3)4-5-7/h3,12H,1-2H3;7H,4-5H2,1-3H3/q;+1/p-1
