4461-52-3Relevant articles and documents
Diastereoselective hydroxymethylation of cyclic N-tert- butanesulfinylketimines using methoxymethanol as formaldehyde source
Priede, Martins,Kazak, Mihail,Kalnins, Toms,Shubin, Kirill,Suna, Edgars
, p. 3715 - 3724 (2014)
Hydroxymethylation of cyclic tert-butanesulfinylketimine-derived lithium enamides with methoxymethanol proceeds with excellent diastereoselectivity (99:1 dr). Methoxymethanol is a stable and easy-to-handle source of anhydrous monomeric formaldehyde in the reaction with lithium enamides. Cyclic α-hydroxymethyl ketimines undergo highly diastereoselective reduction to syn- or anti-1,3-amino alcohols.
Glucose oxidation to formic acid and methyl formate in perfect selectivity
Albert, Jakob,Bukowski, Anna,Kumpidet, Chiraphat,Maerten, Stephanie,Vo?, Dorothea,Wasserscheid, Peter
supporting information, p. 4311 - 4320 (2020/07/14)
We report the highly remarkable discovery that glucose oxidation catalysed by polyoxometalates (POMs) in methanolic solution enables formation of formic acid and methyl formate in close to 100percent combined selectivity, thus with only negligible sugar oxidation to CO2. In detail, we report oxidation of a methanolic glucose solution using H8[PV5Mo7O40] (HPA-5) as catalyst at 90 °C and 20 bar O2 pressure. Experiments with 13C-labelled glucose confirm unambiguously that glucose is the only source of the observed formic acid and methyl formate formation under the applied oxidation conditions. Our results demonstrate a very astonishing solvent effect for the POM-catalysed glucose oxidation. In comparison to earlier work, a step-change in product yield and selectivity is achieved by applying an alcoholic reaction medium. The extremely high combined yields of formic acid and methyl formate greatly facilitate product isolation as low-boiling methyl formate (bp = 32 °C) can simply be isolated from the reaction mixture by distillation.
Method for preparing hemiacetal methanol solution from methanol
-
Paragraph 0039; 0040, (2016/12/01)
The invention discloses a method for preparing a hemiacetal methanol solution from methanol. The method includes oxidizing the methanol to generate a formaldehyde gas mixture, dehydrating the formaldehyde gas mixture, feeding the dehydrated formaldehyde gas mixture into absorption equipment, and enabling the dehydrated formaldehyde gas mixture to contact with a methanol absorbent so as to obtain the hemiacetal methanol solution. The method has the advantages that the methanol is oxidized to obtain the formaldehyde gas mixture, and the methanol absorbent and the dehydrated formaldehyde gas mixture react in the absorption equipment to obtain the hemiacetal methanol solution directly used for glyphosate production, so that smell pollution caused during production of paraformaldehyde is eliminated, a depolymerization process is omitted, a technological process is simplified, and low production energy consumption is achieved by absorbing the formaldehyde in the formaldehyde gas mixture by the methanol absorbent in the absorption equipment.
