4437-01-8 Usage
Description
HEPTAETHYLENE GLYCOL MONOMETHYL ETHER, also known as m-PEG7-alcohol, is a PEG linker containing a hydroxyl group. The hydroxyl group allows for further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer enhances solubility in aqueous media, making it a versatile compound for various applications.
Uses
Used in Bioconjugation:
HEPTAETHYLENE GLYCOL MONOMETHYL ETHER is used as a linker for bioconjugation to facilitate the attachment of biological molecules, such as proteins or nucleic acids, to other molecules or surfaces. The hydrophilic PEG spacer improves the stability and solubility of the conjugated molecules in aqueous environments.
Used in Drug Delivery:
HEPTAETHYLENE GLYCOL MONOMETHYL ETHER is used as a component in drug delivery systems to improve the solubility, stability, and bioavailability of therapeutic agents. The PEG spacer can be used to modify drug molecules or as part of a drug delivery vehicle, such as nanoparticles or liposomes, to enhance their performance.
Used in PEG Hydrogels:
HEPTAETHYLENE GLYCOL MONOMETHYL ETHER is used as a monomer in the synthesis of PEG hydrogels, which are three-dimensional networks of crosslinked polymer chains. These hydrogels have applications in tissue engineering, drug delivery, and as scaffolds for cell culture due to their biocompatibility and tunable physical properties.
Used as a Crosslinker:
HEPTAETHYLENE GLYCOL MONOMETHYL ETHER is used as a crosslinker to connect different molecules or polymer chains, creating a stable and covalently bonded network. This can be useful in the formation of gels, coatings, or other materials with specific mechanical or chemical properties.
Used in Surface Functionalization:
HEPTAETHYLENE GLYCOL MONOMETHYL ETHER is used for surface functionalization to modify the properties of a material's surface, such as its wettability, biocompatibility, or adhesion. The hydrophilic PEG spacer can improve the surface's interaction with biological systems or other materials, making it suitable for applications in sensors, medical devices, or coatings.
Check Digit Verification of cas no
The CAS Registry Mumber 4437-01-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,4,3 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4437-01:
(6*4)+(5*4)+(4*3)+(3*7)+(2*0)+(1*1)=78
78 % 10 = 8
So 4437-01-8 is a valid CAS Registry Number.
InChI:InChI=1/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3
4437-01-8Relevant articles and documents
Quantification of grafted poly(ethylene glycol)-silanes on silicon by time-of-flight secondary ion mass spectrometry
Norrman,Papra,Kamounah,Gadegaard,Larsen
, p. 699 - 708 (2007/10/03)
Silicon grafted monodisperse poly(ethylene glycol) (PEG) silanes with various PEG chain lengths and mixtures of these were systematically analyzed with static time-of-flight secondary ion mass spectrometry (TOF-SIMS). The mass spectra show differences in the various relative signal intensities, an observation that was used to elucidate important aspects of the grafting process. The relationship between PEG-silane fragment ion abundances and Si+ ion abundances were used to (i) qualitatively describe layer thicknesses of grafted mixtures of PEG-silanes on silicon, (ii) construct a calibration curve from which PEG chain length (or molecular mass) can be determined and (iii) quantitatively determine surface mixture compositions of grafted monodisperse PEG-silanes of different chain lengths (3, 7 and 11 PEG units). The results suggest that discrimination does take place in the adsorption process. The PEG-silane with the shorter PEG chain is discriminated for mixtures containing PEG3-silane, whereas the PEG-silane with the longer PEG chain is discriminated in PEG7/PEG11-silane mixtures. The origin of this difference in adsorption behavior is not well understood. Aspects of the grafting process and the TOF-SIMS analyses are discussed. Copyrigh
Hydrophilic Lipids
Heimann, Ulrich,Voegtle, Fritz
, p. 858 - 862 (2007/10/02)
The new triesters of glycerol 1-8 with different oligoethylene glycol carboxylic acids ("hydrophilic lipids") have been synthesized and their complexation with alkali and alkaline earth metal cations has been investigated.
