42791-51-5

Basic information

• Product Name: 2-ACETYL-4-NITROTHIOPHENE
• Synonyms: 2-ACETYL-4-NITROTHIOPHENE;1-(4-Nitrothiophen-2-yl)ethanone
• CAS NO: 42791-51-5
• Molecular Formula: C6H5NO3S
• Molecular Weight: 171.1738
• Mol File: 42791-51-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 280.9 °C at 760 mmHg
• Flash Point: 123.7 °C
• Appearance: /
• Density: 1.399 g/cm³
• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-ACETYL-4-NITROTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-4-NITROTHIOPHENE(42791-51-5)
• EPA Substance Registry System: 2-ACETYL-4-NITROTHIOPHENE(42791-51-5)

Safety Data

• Hazardous Substances Data: 42791-51-5(Hazardous Substances Data)

Usage

Description

2-Acetyl-4-nitrothiophene, with the molecular formula C6H5NO3S, is a yellow crystalline solid that possesses a strong odor. It is a chemical compound commonly utilized in organic synthesis and pharmaceutical research as a building block for the development of various drugs and bioactive molecules.

Uses

Used in Pharmaceutical Research:
2-Acetyl-4-nitrothiophene is used as a building block in pharmaceutical research for the production of various drugs and other bioactive molecules. Its unique chemical structure makes it a valuable component in the synthesis of new compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Acetyl-4-nitrothiophene is employed as a key intermediate for the creation of a wide range of chemical compounds. Its versatility in reactions allows for the development of new molecules with diverse properties and potential uses.

InChI:InChI=1/C6H5NO3S/c1-4(8)6-2-5(3-11-6)7(9)10/h2-3H,1H3

Upstream product

• 88-15-3 2-Acetylthiophene 
• 4565-29-1 5-acetylthiophene-2-carbaldehyde 
• 24647-78-7 methyl 4-nitrothiophene-2-carboxylate 
• 13138-70-0 4-nitro-2-thiophenecarboxylic acid 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 108-24-7 acetic anhydride 

Downstream Products

• 692889-40-0 2-acetyl-4-amino-thiophene 
• 92576-84-6 1-(4-nitro-[2]thienyl)-ethanone-(4-bromo-phenylhydrazone) 

Relevant articles and documents

Ethylammonium nitrate (EAN)/Tf2O and EAN/TFAA: Ionic liquid based systems for aromatic nitration

Acting as in situ sources of triflyl nitrate (TfONO2) and trifluoroacetyl nitrate (CF3COONO2), the EAN/Tf 2O and EAN/TFAA systems, generated via metathesis in the readily available ethylammonium nitrate (EAN) ionic liquid as solvent, are powerful electrophilic nitrating reagents for a wide variety of aromatic and heteroaromatic compounds. Comparative nitration experiments indicate that EAN/Tf2O is superior to EAN/TFAA for nitration of strongly deactivated systems. Both systems exhibit low substrate selectivity (K T/KB = 5-10) in (Figure presented) between values reported for covalent nitrates and preformed nitronium salts.

Synthesis and antibacterial activity of 4,7-dihydro-4-ethyl-7-oxothieno(3,2-b)pyridine-6-carboxylic acids

The synthesis of some new 4,7-dihydro-4-ethyl-7-oxothieno(3,2-b)pyridine-6-carboxylic acids with various substituents on position 2 is described. The evaluation of the anti-bacterial activity of some compounds shows an activity different to those of the thieno(2,3-b)pyridine series.

The Synthesis of 2-Heteroarylimidazopyridin-3-ols and Related Compounds

A reaction between pyridin-2-amine 1-oxides and phenalcyl bromides has been extended to some bromoacetyl heteroaromatic compounds to form the title compounds.The reaction of some 2-aminodiazine 1-oxides with phenacyl bromides has also been studied.The imidazopyrimidne and imidazophthalazine systems have been prepared but reaction of pyrazin-2-amine 1-oxide did not give the desired cyclization.