42588-57-8 Usage
Description
3-Ethoxymethacrolein is a clear yellow liquid that serves as a versatile intermediate in the synthesis of various organic compounds. It is known for its unique chemical properties that make it a valuable component in the production of different molecules.
Uses
Used in Pharmaceutical Synthesis:
3-Ethoxymethacrolein is used as a key intermediate for the synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), which is an important compound in the development of pharmaceuticals targeting various health conditions.
Used in Organic Chemistry:
In the field of organic chemistry, 3-Ethoxymethacrolein is utilized as a starting material for the modified Friedlander synthesis, which is a method for the preparation of quinolines. Quinolines are a class of compounds with diverse applications, including their use as antimalarial, anticancer, and antituberculous agents.
Used in Fragrance Industry:
3-Ethoxymethacrolein is also used as a building block for the creation of 3-[2-isopropyl-5-methylcyclohexyloxy-(1R, 2S, 5R)]-2-methyl-2E-propenal, a compound that contributes to the development of unique fragrances and scents in the perfumery and fragrance industry.
These applications highlight the multifaceted nature of 3-Ethoxymethacrolein, showcasing its importance in various industries, from pharmaceuticals to organic chemistry and the fragrance sector.
Check Digit Verification of cas no
The CAS Registry Mumber 42588-57-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,5,8 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 42588-57:
(7*4)+(6*2)+(5*5)+(4*8)+(3*8)+(2*5)+(1*7)=138
138 % 10 = 8
So 42588-57-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H10O2/c1-3-8-5-6(2)4-7/h4-5H,3H2,1-2H3/b6-5+
42588-57-8Relevant articles and documents
A facile route to 3-alkoxy-2-methylpropenals, useful intermediates in the synthesis of carotenoids
Babler, James H.,Liptak, Vincent P.,Trautmann, Jeffrey A.,Zayia, Gregory H.
, p. 1943 - 1951 (1996)
A 'one-pot' process for the preparation of a carotenoid synthon (4) has been developed that involves methoxide-promoted condensation of propionaldehyde with methyl formate, followed by exclusive O-alkylation of the resultant stabilized enolate (6).
Oxopropenylation of Alkylmagnesium Halides by 3-(Trimethylsilyloxy)acroleins
Ullrich, Friedrich-Wilhelm,Rotscheidt, Klaus,Breitmaier, Eberhard
, p. 1737 - 1744 (2007/10/02)
Oxopropenylation of alkylmagnesium halides 4 by 3-(trimethylsilyloxy)acroleins 3 selectively yields the (E)-isomers of α,β-unsaturated aldehydes such as 4-phenyl-2-butenals 9, 3-cyclopropylpropenals 10, 3-cyclohexylpropenals 11, 3-(3-menthyl)propenals 12, and 2,5-hexadienals 13. 3-Hydroxyenolsilylethers 6 are isolated when allylmagnesium chloride is used as carbon nucleophile; to conclude, the reaction primarily involves nucleophilic addition of the Grignard reagent at the aldehyde carbon of the acrolein 3.