42521-82-4 Usage
Description
1,1'-Dithiodi-2-naphthtol is an organic disulfide compound that is obtained through the oxidative dimerization of 1-sulfanylnaphthalen-2-ol. It is a chemical compound with unique properties that make it useful in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
1,1'-Dithiodi-2-naphthtol is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
1,1'-Dithiodi-2-naphthtol is used as a reagent in chemical synthesis processes. Its disulfide bond can be exploited in various chemical reactions, making it a valuable tool for chemists working on the development of new molecules and materials.
Used in Research and Development:
1,1'-Dithiodi-2-naphthtol is used as a research compound in the field of organic chemistry. Its properties and reactivity make it an interesting subject for study, and it can be used to explore new reaction pathways and mechanisms.
Used in Material Science:
1,1'-Dithiodi-2-naphthtol can be used in the development of new materials with specific properties. Its disulfide bond can be utilized to create materials with unique electronic, optical, or mechanical characteristics.
Biological Activity
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM in a cell-free assay, no inhibition to group II PAKs (PAKs 4-6).
Biochem/physiol Actions
IPA-3 is an allosteric inhibitor of Pak1. It binds to autoinhibitory domain of Pak1 (p21 activated kinase), highly selective amongst kinases. Pak1 is implicated in tumorigenesis and metastasis.
in vitro
IPA-3 is a non ATP-competitive, allosteric inhibitor of p21-activated kinase 1 (Pak1). PIR3.5 is the control compound of IPA-3. IPA-3 prevents Cdc42-stimulated Pak1 autophosphorylation on Thr423. IPA-3 also prevents sphingosine-dependent Pak1 autophosphorylation. IPA-3 does not target exposed cysteine residues on Pak1. The disulfide bond of IPA-3 is critical for inhibition of Pak1 and in vitro reduction by the reducing agent dithiothreitol (DTT) abolishes Pak1 inhibition by IPA-3. IPA-3 inhibits activation of Pak1 by diverse activators, but does not inhibit preactivated Pak1. IPA-3 inhibits PDGF-stimulated Pak activation in mouse embryonic fibroblasts. IPA-3 inhibits Pak1 activation in part by binding covalently to the regulatory domain of Pak1. IPA-3 binds Pak1 covalently in a time- and temperature-dependent manner. IPA-3 prevents binding of the Pak1 activator Cdc42. IPA-3 binds directly to the Pak1 autoregulatory domain. IPA-3 reversibly inhibits PMA-induced membrane ruffling in cells.
References
1) Deacon?et al.?(2008)?An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase; Chem.Biol.,?14?322
2) Viaud and Peterson (2009)?An allosteric kinase inhibitor binds the p21-activated kinase (PAK) autoregulatory domain covalently; Mol. Cancer Ther.,?8?2559
3) Kuzelova?et al. (2014)?Group 1 PAK Inhibitor IPA-3 Induces Cell Death and Affects Cell Adhesivity to Fibronectin in Human Hematopoietic Cells; PLoS One,?9?e92560
4) Al-Azayzih?et al.?(2015)?P21 Activated Kinase-1 Mediates Transforming Growth factor b1-Induced Prostate Cancer Cell Epithelial to Mesenchymal transition; Biochim. Biophys. Acta,?1853?1229
5) Wong?et al.?(2013)?IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-kB Activation; PLoS One,?8?e68843
Check Digit Verification of cas no
The CAS Registry Mumber 42521-82-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,5,2 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 42521-82:
(7*4)+(6*2)+(5*5)+(4*2)+(3*1)+(2*8)+(1*2)=94
94 % 10 = 4
So 42521-82-4 is a valid CAS Registry Number.
