4251-65-4Relevant articles and documents
Oxidation of certain 4-substituted phenethyl alcohols with Collins reagent: On the mechanism of a carbon-carbon bond cleavage
Li,Johnson
, p. 533 - 537 (1995)
A mechanism is proposed for a carbon-carbon bond cleavage observed in the oxidation of certain 4-substituted phenethyl alcohols with Collins reagent.
Synthetic Access to gem-Difluoropropargyl Vinyl Ethers and Their Application to Propargyl Claisen Rearrangement
Okamura, Toshitaka,Koyamada, Kenta,Kanazawa, Junichiro,Miyamoto, Kazunori,Iwabuchi, Yoshiharu,Uchiyama, Masanobu,Kanoh, Naoki
, p. 1911 - 1924 (2020/12/23)
With the increasing importance of fluorine to medicinal chemistry and other areas, methods to access various fluorinated compounds are needed. Herein, we report the synthesis of difluoropropargyl vinyl ethers from ketones and aldehydes using difluoropropargyl bromide dicobalt complexes. We applied difluoropropargyl vinyl ethers to the synthesis of difluorodienone or difluoroallene under thermal conditions and trifluoro-pyran under acid-catalyzed conditions.
High-Level Production of Phenylacetaldehyde using Fusion-Tagged Styrene Oxide Isomerase
Choo, Joel P. S.,Kammerer, Richard A.,Li, Xiaodan,Li, Zhi
, p. 1714 - 1721 (2021/02/12)
An order-of-magnitude improvement in the production of phenylacetaldehyde to 3.37 M (405 g L?1) from the enzymatic isomerisation of styrene oxide was achieved. A small ubiquitin-related modifier (SUMO) tag increases the productivity of the whole-cell biocatalytic system by enhancing the expression of active membrane-bound styrene oxide isomerase (SOI) while retaining enzyme catalytic efficiency and broad natural substrate scope. The isomerisation was performed by using Escherichia coli expressing SUMO-tagged SOI in an organic-aqueous biphasic system to yield 96% of phenylacetaldehyde. (Figure presented.).