4235-89-6

Basic information

• Product Name: Phenol, 4-(1,1-dimethylethyl)-, phosphite (3:1)
• CAS NO: 4235-89-6
• Molecular Formula: C30H39O3P
• Molecular Weight: 478.612
• Mol File: 4235-89-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Phenol, 4-(1,1-dimethylethyl)-, phosphite (3:1)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-(1,1-dimethylethyl)-, phosphite (3:1)(4235-89-6)
• EPA Substance Registry System: Phenol, 4-(1,1-dimethylethyl)-, phosphite (3:1)(4235-89-6)

Safety Data

• Hazardous Substances Data: 4235-89-6(Hazardous Substances Data)

Upstream product

• 98-54-4 para-tert-butylphenol 
• 96-76-4 2,4-di-tert-Butylphenol 

Downstream Products

• 78-33-1 tri-p-tert-butylphenol phosphate ester 
• 890136-18-2 C₃₅H₃₉N₂O₇P 
• 1282624-24-1 C₃₀H₃₈NO₅P 
• 1282624-46-7 C₃₂H₄₂NO₅P 
• 1312758-96-5 1-formamido-2-methylpropanephosphonic acid di(4-tert-butylphenyl) ester 
• 915299-24-0 tris(2,4-di-tert-butylphenyl)phosphite gold(I) chloride 
• 1394940-72-7 C₅₁H₅₅N₂O₆P 
• 1402800-56-9 BrH*C₂₄H₃₆NO₃P 
• 1402801-47-1 BrH*C₂₂H₃₂NO₃P 

Relevant articles and documents

Diphenyl Diselenide-Catalyzed Synthesis of Triaryl Phosphites and Triaryl Phosphates from White Phosphorus

Industrially important triaryl phosphites, traditionally prepared from PCl3, have been synthesized by a diphenyl diselenide-catalyzed one-step procedure involving white phosphorus and phenols, which provides a halogen- and transition metal-free way to these compounds. Subsequent oxidation of triaryl phosphites produces triaryl phosphates and triaryl thiophosphates. Phosphorotrithioates are also prepared efficiently from aromatic thiols and aliphatic thiols.

Phosphonic Analogs of Alanine as Acylpeptide Hydrolase Inhibitors

Acylpeptide hydrolase is a serine protease, which, together with prolyl oligopeptidase, dipeptidyl peptidase IV and oligopeptidase B, belongs to the prolyl oligopeptidase family. Its primary function is associated with the removal of N-acetylated amino acid residues from proteins and peptides. Although the N-acylation occurs in 50–90 % of eukaryotic proteins, the precise functions of this modification remains unclear. Recent findings have indicated that acylpeptide hydrolase participates in various events including oxidized proteins degradation, amyloid β-peptide cleavage, and response to DNA damage. Considering the protein degradation cycle cross-talk between acylpeptide hydrolase and proteasome, inhibition of the first enzyme resulted in down-regulation of the ubiquitin-proteasome system and induction of cancer cell apoptosis. Acylpeptide hydrolase has been proposed as an interesting target for the development of new potential anticancer agents. Here, we present the synthesis of simple derivatives of (1-aminoethyl)phosphonic acid diaryl esters, phosphonic analogs of alanine diversified at the N-terminus and ester rings, as inhibitors of acylpeptide hydrolase and discuss the ability of the title compounds to induce apoptosis of U937 and MV-4-11 tumor cell lines.

Human neutrophil elastase phosphonic inhibitors with improved potency of action

Herein, we present the synthesis and the measurement of the inhibitory activity of novel peptidyl derivatives of α-aminoalkylphosphonate diaryl esters as human neutrophil elastase inhibitors. Their selectivity against other serine proteases, including porcine pancreatic elastase, chymotrypsin, and trypsin, was also demonstrated. We also describe the preparation of single peptide diastereomers. The most active and selective compound developed possessed a kinact/KI of 2353000 M-1 s -1, which is the most potent irreversible peptidyl inhibitor of human neutrophil elastase reported to date. The peptidyl inhibitors were demonstrated to be stable in PBS buffer and human plasma, as were their complexes with HNE.