4224-87-7

Basic information

• Product Name: 3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one
• Synonyms: 3-(4-Methylphenyl)-1-phenyl-2-propen-1-one;4-Methylstyrylphenyl ketone;p-Methylchalcone;β-(4-Methylphenyl)acrylophenone;β-p-Tolylacrylophenone;2-Propen-1-one, 3-(4-Methylphenyl)-1-phenyl-
• CAS NO: 4224-87-7
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.30
• Product Categories: Chalcones
• Mol File: 4224-87-7.mol
• Article Data: 261

Chemical Properties

• Boiling Point: 303.46°C (rough estimate)
• Flash Point: 157.7°C
• Appearance: /
• Density: 1.0688 (rough estimate)
• Vapor Pressure: 1.79E-05mmHg at 25°C
• Refractive Index: 1.4600 (estimate)
• CAS DataBase Reference: 3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one(4224-87-7)
• EPA Substance Registry System: 3-(4-methylphenyl)-1-phenyl-prop-2-en-1-one(4224-87-7)

Safety Data

• Hazardous Substances Data: 4224-87-7(Hazardous Substances Data)

Usage

Safety Profile

A poison by intraperitoneal route. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating vapors.

InChI:InChI=1/C16H14O/c1-13-7-9-14(10-8-13)11-12-16(17)15-5-3-2-4-6-15/h2-12H,1H3/b12-11+

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 98-86-2 acetophenone 
• 10325-68-5 2,3-dibromo-1-phenyl-3-p-tolyl-propan-1-one 
• 32120-82-4 bis(benzoylmethyl) sulfoxide 
• 70-11-1 α-bromoacetophenone 
• 5399-30-4 2-oxo-2-phenylethylthiocyanate 
• 134539-86-9 1-methyl-4-(3-phenyl-2-propen-1-yl)benzene 
• 589-18-4 4-Methylbenzyl alcohol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 201230-82-2 carbon monoxide 
• 17763-67-6 Phenyl triflate 
• 536-74-3 phenylacetylene 
• 109-77-3 malononitrile 
• 22252-14-8 (E)-3-(4-methylphenyl)-1-phenyl-2-propen-1-one 

Downstream Products

• 1669-50-7 1-phenyl-3-(4-tolyl)propan-1-one 
• 55861-07-9 2,3,3,6-Tetraphenyl-4-(p-tolyl)-3,4-dihydro-1,2λ⁵-oxaphosphorin-2-on 
• 55860-85-0 4-(4-methyl-styryl)-2,3,3,4-tetraphenyl-[1,2]oxaphosphetane 2-oxide 
• 41231-89-4 1,1-Diphenyl-3-p-tolyl-2-propen-1-ol 
• 10325-68-5 2,3-dibromo-1-phenyl-3-p-tolyl-propan-1-one 
• 121567-87-1 5-Phenyl-7-p-tolyl-4,7-dihydro-tetrazolo[1,5-a]pyrimidine 
• 74007-52-6 3,3-Dimethoxy-1-phenyl-2-p-tolyl-propan-1-one 
• 96570-14-8 6-Benzoyl-3-methoxy-5-p-tolyl-cyclohex-2-enone 
• 344242-28-0 6-Benzoyl-3-phenyl-5-p-tolyl-cyclohex-2-enone 
• 75703-54-7 diethyl 5-phenyl-3-(p-tolyl)-3,4-dihydro-2H-pyrrole-2,2-dicarboxylate 
• 78572-57-3 1-Benzoyl-2-p-tolyl-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid ethyl ester 
• 130317-99-6 1,5-diphenyl-3-(p-methylphenyl)-1,5-pentanedione 
• 3558-65-4 4-(4-methylphenyl)-2,6-diphenylpyridine 
• 116709-36-5 Phenyl-(2-phenyl-5-thiophen-2-yl-4-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-methanone 

Relevant articles and documents

Micellar Catalysis Strategy of Cross-Condensation Reaction: The Effect of Polar Heads on the Catalytic Properties of Aminoalcohol-Based Surfactants

Abstract: The effect of the polar head and the concentration of quaternary ammonium surfactants (C14EtOH, C14iPrOH, C14PrOH, where, 14 = carbon number iPrOH = iso-propanol, EtOH = ethanol, PrOH = propanol) in micellar cata

Electronically tuneable orthometalated RuII–NHC complexes as efficient catalysts for C–C and C–N bond formations via borrowing hydrogen strategy

The catalytic activities of a series of simple and electronically tuneable cyclometalated RuII–NHC complexes (2a–d) were explored in various C–C/N bond formations following the borrowing hydrogen process. Slight modifications in the ligand backbone were noted to tune the activities of these complexes. Among them, the complex 2d featuring a 1,2,4-triazolylidene donor with a 4-NO2–phenyl substituent displayed the highest activity for the coupling of diverse secondary and primary alcohols with a low catalyst loading of 0.01 mol% and a sub-stoichiometric amount of inexpensive KOH base. The efficacy of this simple system was further showcased in the challenging one-pot unsymmetrical double alkylation of secondary alcohols using different primary alcohols. Moreover, the complex 2d also effectively catalyses the selective mono-N-methylation of various aromatic and aliphatic primary amines using methanol to deliver a range of N-methyl amines. Mechanistically, the β-alkylation reaction follows a borrowing hydrogen pathway which was established by the deuterium labelling experiment in combination with various control experiments. Intriguingly, in situ1H NMR and ESI-MS analyses evidently suggested the involvement of a Ru–H species in the catalytic cycle and further, the kinetic studies revealed a first order dependence of the reaction rate on the catalyst as well as the alcohol concentrations.

One-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions: Atom-economic synthesis of selenocarbamates and allyl sulfones

In many reactions involving selenosulfonate or thiosulfonate, the sulfone group often leaves in form of benzenesulfinic acid or sodium benzenesulfinate. A one-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions to afford selenocarbamates and allyl sulfone compounds is reported. The sulfinic acid as the first-step side product is converted to the allyl sulfone compound by water promoted reaction with allyl alcohol. Water acts as both an oxygen source of selenocarbamates and as a promoter to drive the second step reaction. The reactions have the advantages of mild conditions, green, environment-friendly, and high atomic economy.