42152-55-6

Basic information

• Product Name: N-(5-CHLORO-THIOPHEN-2-YL)-ACETAMIDE
• Synonyms: N-(5-CHLORO-THIOPHEN-2-YL)-ACETAMIDE
• CAS NO: 42152-55-6
• Molecular Formula: C₆H₆ClNOS
• Molecular Weight: 175.63594
• Mol File: 42152-55-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 336.722 °C at 760 mmHg
• Flash Point: 157.444 °C
• Appearance: /
• Density: 1.417 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: N-(5-CHLORO-THIOPHEN-2-YL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-CHLORO-THIOPHEN-2-YL)-ACETAMIDE(42152-55-6)
• EPA Substance Registry System: N-(5-CHLORO-THIOPHEN-2-YL)-ACETAMIDE(42152-55-6)

Safety Data

• Hazardous Substances Data: 42152-55-6(Hazardous Substances Data)

Usage

General Description

N-(5-chloro-thiophen-2-yl)-acetamide is a chemical compound with the molecular formula C8H8ClNO and a molecular weight of 173.61 g/mol. It is a derivative of acetamide, with a chloro-thiophene group attached to the nitrogen atom. N-(5-CHLORO-THIOPHEN-2-YL)-ACETAMIDE has potential pharmaceutical applications due to its structural similarity to other biologically active molecules. It may have uses in the development of new drugs, particularly in the treatment of neurological disorders or as a potential analgesic. Further research is needed to explore its potential therapeutic properties and biological activities.

InChI:InChI=1/C6H6ClNOS/c1-4(9)8-6-3-2-5(7)10-6/h2-3H,1H3,(H,8,9)

Upstream product

• 42520-87-6 C₆H₆ClNOS 
• 42520-87-6 (E)-1-(5-chlorothiophen-2-yl)ethan-1-one oxime 
• 63806-71-3 (5-chloro-thiophen-2-yl)-carbamic acid tert-butyl ester 
• 108-24-7 acetic anhydride 
• 7647-01-0 hydrogenchloride 
• 598-49-2 N-chloroacetamide 
• 97799-95-6 5-chloro-2-acetylthiophene oxime benzenesulfonate 

Downstream Products

• 1353894-34-4 2,6-dichlorothieno[2,3-b]pyridine-5-carbaldehyde 
• 679794-81-1 N-(5-chloro-3-formyl-2-thienyl) acetamide 
• 679794-83-3 methyl N-acetyl-N-(5-chloro-3-formyl-2-thienyl)glycinate 

Relevant articles and documents

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HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF THE THIENOPYRROLE DERIVATIVES

A process for preparing a compound of formula (I) where R4 and R5are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4, R5and R6 are as defined in relation to formula (I) and R7is a nitrogen-protecting group, and removing protecting group R7-, and thereafter if desired or necessary, removing any protecting group R6 to obtain the corresponding carboxylic acid. Novel intermediates and the use of the products in the preparation of pharmaceutical compounds is also described and claimed