421-49-8 Usage
Description
1,1,1-TRIFLUORO-ISOPROPYLAMINE, also known as 1-(Trifluoromethyl)ethylamine, is a fluorinated propanamine derivative with unique chemical properties. It is characterized by the presence of a trifluoromethyl group attached to an isopropylamine moiety, which imparts specific reactivity and stability to the molecule. 1,1,1-TRIFLUORO-ISOPROPYLAMINE is a versatile building block in the synthesis of various pharmaceutical compounds, making it a valuable intermediate in the development of new drugs.
Uses
Used in Pharmaceutical Industry:
1,1,1-TRIFLUORO-ISOPROPYLAMINE is used as a building block for the synthesis of pharmaceutical compounds, specifically for the development of hNav1.7 channel blockers and anti-cancer agents. Its unique chemical properties and reactivity make it an essential component in the creation of these therapeutic agents.
1,1,1-TRIFLUORO-ISOPROPYLAMINE is used as a key intermediate in the synthesis of hNav1.7 channel blockers for the treatment of pain management. 1,1,1-TRIFLUORO-ISOPROPYLAMINE's ability to form stable and bioactive molecules allows for the development of effective pain relief medications with fewer side effects.
Additionally, 1,1,1-TRIFLUORO-ISOPROPYLAMINE is used in the synthesis of anti-cancer agents, where it contributes to the development of drugs that target and inhibit the growth of cancer cells. Its unique structure and reactivity enable the creation of potent and selective cancer therapies, offering new treatment options for patients with various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 421-49-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 421-49:
(5*4)+(4*2)+(3*1)+(2*4)+(1*9)=48
48 % 10 = 8
So 421-49-8 is a valid CAS Registry Number.
421-49-8Relevant articles and documents
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Shepard,R.A.,Sciaraffa,P.L.
, p. 964 - 965 (1966)
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Economical and practical strategies for synthesis of α-trifluoromethylated amines
Jiang,Cheng,Yuan
, p. 2406 - 2408 (2016/05/19)
A powerful approach to synthesize α-trifluoromethylated amines has been developed. The method is operationally simple, broad in substrate scope and amenable to scale-up using trifluoroacetic anhydride. Meanwhile, the strategy not only provided a versatile approach to synthesize α-trifluoromethylated amines but also provides a new method for exploring the new reactivity of trifluoroacetic anhydride.
Biomimetic reductive amination under the continuous-flow reaction conditions
Soloshonok, Vadim A.,Catt, Hector T.,Ono, Taizo
body text, p. 261 - 265 (2010/04/05)
This study present a full account of continuous-flow reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1,3-proton shift reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features operationally convenient conditions, higher chemical yields, enantioselectivity and purity of the corresponding products as compared with traditional in-flask reactions. Moreover the removal of base-catalyst, the most delicate problem of the in-flask reactions, is not an issue in the on-column process, as the silica-adsorbed DBU or polymer-bound guanidine remains on the column and can be reused. This feature renders the overall process substantially more economical and synthetically efficient, in particular, for large-scale synthesis of the corresponding fluorinated amines and amino acids target.