41661-47-6 Usage
Description
4-Piperidinone, a derivative of piperidine with the molecular formula C5H9NO, is a class of chemical compounds sharing the piperidone skeleton. It is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs. The synthesis of piperidones can be achieved through the Petrenko-Kritschenko piperidone synthesis, a multicomponent reaction involving the combination of alkyl-1,3-acetonedicarboxylate, benzaldehyde, and an amine.
Uses
Used in Pharmaceutical Industry:
4-Piperidinone is used as an intermediate for the synthesis of various pharmaceutical drugs. Its unique chemical structure allows it to be incorporated into a wide range of medications, contributing to their therapeutic effects.
Used in Chemical Industry:
In the chemical industry, 4-Piperidinone serves as a key intermediate in the production of various chemical compounds. Its versatile structure makes it a valuable building block for the development of new and innovative products.
Used in Research and Development:
4-Piperidinone is utilized in research and development for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique properties make it an interesting subject for scientific investigation and potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 41661-47-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,6,6 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 41661-47:
(7*4)+(6*1)+(5*6)+(4*6)+(3*1)+(2*4)+(1*7)=106
106 % 10 = 6
So 41661-47-6 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO/c7-5-1-3-6-4-2-5/h6H,1-4H2
41661-47-6Relevant articles and documents
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Kucherova et al.
, (1973)
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TEAD INHIBITORS AND USES THEREOF
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Paragraph 00465; 00813, (2020/12/11)
The present invention provides compounds, compositions thereof, and methods of using the same.
Synthesis method of intermediate 4-piperidone
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Paragraph 0022-0056, (2019/12/02)
The invention discloses a synthesis method of an intermediate 4-piperidone. The method comprises the following steps: adding beta-alanine methyl ester into ethanol, placing the raw material into a reaction kettle, adding ethylene, uniformly mixing the raw materials, cooling the raw materials to 0-10 DEG C, adding a catalyst aid and sodium ethoxide, stirring the raw materials for reaction, and cooling a reaction product to room temperature after the reaction is finished; and performing reduced pressure distillation to remove ethanol; adding DMF into a reaction kettle, uniformly stirring and mixing the components, heating the mixture to 110-130 DEG C, and carrying out reflux reaction under a stirring condition for 1-2 hours; cooling the reaction product to room temperature, extracting the reaction product with ethyl acetate, performing evaporation to remove ethyl acetate, and carrying out reduced pressure distillation to obtain the 4-piperidone. The synthesis method disclosed by the invention adopts a one-pot method, does not need an intermediate purification step, reduces resource waste, is simple to operate, short in production process, high in raw material conversion rate and relatively low in production cost, and has relatively high economic benefits.