40890-47-9

Basic information

• Product Name: 2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE
• Synonyms: 2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE;2-BENZYL-4-CHLORO-5-METHOXYPYRIDAZIN-3(2H)-ONE
• CAS NO: 40890-47-9
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.68
• Mol File: 40890-47-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 395.5 °C at 760 mmHg
• Flash Point: 193 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 1.83E-06mmHg at 25°C
• Refractive Index: 1.591
• CAS DataBase Reference: 2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE(40890-47-9)
• EPA Substance Registry System: 2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE(40890-47-9)

Safety Data

• Hazardous Substances Data: 40890-47-9(Hazardous Substances Data)

Usage

General Description

2-BENZYL-4-CHLORO-5-METHOXY-3(2H)-PYRIDAZINONE, also known as BM-611, is a chemical compound with potential therapeutic properties. It is a pyridazinone derivative with a benzyl group and a chloro-methoxy substitution. BM-611 has been studied for its potential as an anti-inflammatory and anti-cancer agent. It has shown promise in inhibiting the growth of certain cancer cells and reducing inflammation in experimental models. Additionally, BM-611 has been investigated for its potential as an antifungal and antiviral agent. Further research is needed to fully understand the pharmacological properties and potential uses of this compound.

InChI:InChI=1/C12H11ClN2O2/c1-17-10-7-14-15(12(16)11(10)13)8-9-5-3-2-4-6-9/h2-7H,8H2,1H3

Upstream product

• 124-41-4 sodium methylate 
• 41933-33-9 2-benzyl-4,5-dichloro-3(2H)-pyridazinone 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 67-56-1 methanol 
• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 

Downstream Products

• 40890-51-5 2-benzyl-4-chloro-5-hydroxy-2H-pyridazin-3-one 
• 476172-02-8 2-(2-benzyl-5-methoxy-3-oxo-2,3-dihydropyridazin-4-yl)benzaldehyde 
• 603128-12-7 2-benzyl-5-methoxy-4-phenylpyridazin-3(2H)-one 
• 938045-28-4 2-benzyl-5-methoxy-4-methylpyridazin-3(2H)-one 
• 929190-86-3 2-benzyl-4-(4-chlorophenyl)-5-methoxypyridazin-3(2H)-one 
• 929190-88-5 2-benzyl-5-hydrazino-4-phenylpyridazin-3(2H)-one 
• 929190-89-6 2-benzyl-4-(4-chlorophenyl)-5-hydrazinopyridazin-3(2H)-one 
• 929190-91-0 5-azido-2-benzyl-4-phenylpyridazin-3(2H)-one 
• 929190-92-1 5-azido-2-benzyl-4-(4-chlorophenyl)pyridazin-3(2H)-one 
• 929190-93-2 2-benzyl-2,5-dihydro-pyridazino[4,5-b]indol-1-one 
• 929190-96-5 2-benzyl-5-propyl-2,5-dihydro-pyridazino[4,5-b]indol-1-one 
• 938045-29-5 2-benzyl-5-hydroxy-4-methylpyridazin-3(2H)-one 
• 938045-30-8 C₁₂H₁₁ON₂OCF₃SO₂ 
• 938045-31-9 2-benzyl-5-(2-formylphenyl)-4-methylpyridazin-3(2H)-one 

Relevant articles and documents

Synthesis of Novel Pyridazino[4,5-b][1,4]oxazine-3,5-diones

Novel pyridazino[4,5-b][1,4]oxazine-3,5-diones were synthesized from N-[2-(3,4-dimethoxyphenyl)-ethyl]-2-chloroacetamide (or 2-chloropropanamide) and 1-alkyl-5-halo-4-hydroxypyridazin-6-ones in good yield.

Synthesis of the dibenzo[f,h]phthalazine and dibenzo[f,h]cinnoline skeleton via a 'Suzuki-Pd-catalyzed intramolecular arylation' and a 'Suzuki-Pschorr' approach

Palladium-catalyzed intramolecular arylation of 2-benzyl-5-(2-bromophenyl)-4-phenylpyridazin-3(2H)-one yielded hitherto unknown 2-benzyldibenzo[f,h]phthalazin-1(2H)-one. The synthesis of this new tetracyclic pyridazinone from 2-benzyl-5-(2-aminophenyl)-4-phenylpyridazin-3(2H)-one via a Pschorr type reaction was also investigated. Similarly, the construction of 2-methyldibenzo[f,h]cinnolin-3(2H)-one from 2-methyl-5-(2-bromophenyl)-6-phenylpyridazin-3(2H)-one and 2-methyl-5-(2-aminophenyl)-6-phenylpyridazin-3(2H)-one is also reported. Removal of the N-benzyl protective group of 2-benzyl-dibenzo[f,h]phthalazin-1(2H)-one with AlCl3 yielded unsubstituted dibenzo[f,h]phthalazin-1(2H)-one.

Synthesis of new pyridazino[4,5-c]isoquinolinones by Suzuki cross-coupling reaction

Suzuki cross-coupling reaction of 2-alkyl(methyl and benzyl)-5-chloro-4-methoxy- and 2-alkyl(methyl and benzyl)-4-chloro-5-methoxypyridazin-3(2H)-ones with 2-formylphenylboronic acid afforded the corresponding biaryl products which were cyclized with ammonia to yield hitherto undescribed pyridazino[4,5-c]isoquinolinones. Removal of the N-benzyl protective group in position 2 yielded the unsubstituted tricyclic pyridazinones.