406-87-1Relevant articles and documents
Electrochemical Synthesis of 4,4,4-Trifluorobutanal
Muller, Norbert
, p. 4559 - 4560 (1984)
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Highly selective hydroformylation of 3,3,3-trifluoropropene to 4,4,4-trifluorobutanal using Rh/Xantphos catalyst
Ohtsuka, Yuhki,Kobayashi, Osamu,Yamakawa, Tetsu
, p. 34 - 40 (2014)
Synthesis of 4,4,4-trifluorobutanal by Rh-catalyzed hydroformylation of 3,3,3-trifluoropropene with bis(4,5-diphenylphosphino)xanthene as a ligand was investigated. The uses of [Rh(OH)(cod)]2 (cod = 1,5-cyclooctadinene) and dimethylformamide in CO/H2 = 75/25 mixed gas under atmospheric pressure at 80 C for 15 h provided the highest aldehyde yield 90%. The molar ratio of linear aldehyde (4,4,4-trifluorobutanal) to branched aldehyde (3,3,3-trifluoro-2-methylpropanal) was 99/1. The successive addition of dimethylformamide solution of 3,3,3-trifluoropropene under atmospheric pressure revealed that 4,4,4-trifluorobutanal formation increased linearly with the reaction time and the total turnover number reached 500 after 10 h retaining 99% selectivity of 4,4,4-trifluorobutanal at 80 C.
MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF
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Paragraph 00192; 00193; 00194, (2018/11/22)
The present invention provides compounds, compositions thereof, and methods of using the same.
3-(PERFLUOROALKYL)PROPANAL PRODUCTION METHOD
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Paragraph 0033-0036; 0038-0061; 0063-0075; 0077-0079, (2018/10/31)
PROBLEM TO BE SOLVED: To provide a method of producing 3-(perfluoroalkyl)propanal with high selectivity, which is an important compound as a fluorine-containing building block for drug and functional material synthesis. SOLUTION: (Perfluoroalkyl)ethylene represented by the general formula (2) is reacted with carbon monoxide and hydrogen in the presence of a rhodium compound and diphosphine to produce 3-(perfluoroalkyl)propanal represented by the general formula (3). (In the formulas, Rf represents the same C1-16 perfluoroalkyl group.) COPYRIGHT: (C)2015,JPOandINPIT