40516-57-2

Basic information

• Product Name: 5-CHLOROMETHYL-2-ISOPROPYL-THIAZOLE
• Synonyms: 5-CHLOROMETHYL-2-ISOPROPYL-THIAZOLE;4-(chloroMethyl)-2-(propan-2-yl)-1,3-thiazole;4-(Chloromethyl)-2-(prop-2-yl)-1,3-thiazole;2-Isopropyl-4-(chloromethyl)thiazole
• CAS NO: 40516-57-2
• Molecular Formula: C₇H₁₀ClNS
• Molecular Weight: 175.68
• Mol File: 40516-57-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 235.8 °C at 760 mmHg
• Flash Point: 96.4 °C
• Appearance: /
• Density: 1.171 g/cm³
• Vapor Pressure: 0.0752mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 5-CHLOROMETHYL-2-ISOPROPYL-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROMETHYL-2-ISOPROPYL-THIAZOLE(40516-57-2)
• EPA Substance Registry System: 5-CHLOROMETHYL-2-ISOPROPYL-THIAZOLE(40516-57-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 40516-57-2(Hazardous Substances Data)

Usage

General Description

5-Chloromethyl-2-isopropyl-thiazole is a chemical compound with the molecular formula C8H12ClNS. It is a thiazole derivative with a chloromethyl substitution at the 5 position and an isopropyl group at the 2 position. 5-Chloromethyl-2-isopropyl-thiazole is used primarily as a building block in organic synthesis and pharmaceutical manufacturing. It may also have applications in the development of agrochemicals or other specialty chemicals. 5-Chloromethyl-2-isopropyl-thiazole is a pale yellow liquid with a characteristic odor, and it should be handled and stored according to standard safety procedures for handling organic compounds.

InChI:InChI=1/C7H10ClNS/c1-5(2)7-9-6(3-8)4-10-7/h4-5H,3H2,1-2H3

Upstream product

• 13515-65-6 thioisobutyramide 
• 534-07-6 1,3-Dichloroacetone 
• 133047-45-7 ethyl (2-isopropylthiazol-4-yl)methanol 

Downstream Products

• 154212-60-9 N-methyl-N-<(2-isopropyl-4-thiazolyl)methyl>amine 

Relevant articles and documents

A 2 - isopropyl -4 - (methyl amino methyl) thiazole synthesis method (by machine translation)

The invention discloses a 2 - isopropyl - 4 - (methyl amino methyl) thiazole synthesis method, in order to 2, 2 - dimethyl - 4 - methylene - 1, 3 - dioxane as the starting material, with a halo reagent addition reaction with a further thio isobutyramide after condensation to produce 2 - isopropyl - 4 - hydroxymethyl thiazole, through chlorination obtained after 2 - isopropyl - 4 - chloro methyl thiazole, finally with the methylamine substitution reaction, to obtain 2 - isopropyl - 4 - (methyl amino methyl) thiazole. The method of the invention novel routes, to avoid the use of toxic chemicals as the raw material, the operation is simple, mild condition, has the potential development of industrialization. (by machine translation)

Structure-activity relationships of diamine inhibitors of cytochrome P450 (CYP) 3A as novel pharmacoenhancers. Part II: P2/P3 region and discovery of cobicistat (GS-9350)

The HIV protease inhibitor (PI) ritonavir (RTV) has been widely used as a pharmacoenhancer for other PIs, which are substrates of cytochrome P450 3A (CYP3A). However the potent anti-HIV activity of ritonavir may limit its use as a pharmacoenhancer with other classes of anti-HIV agents. Ritonavir is also associated with limitations such as poor physicochemical properties. To address these issues a series of compounds with replacements at the P2 and/or P3 region was designed and evaluated as novel CYP3A inhibitors. Through these efforts, a potent and selective inhibitor of CYP3A, GS-9350 (cobicistat) with improved physiochemical properties was discovered.

Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical composition comprising the same

Benzhydrylpiperazinyl Thiazole compounds of the formula STR1 wherein R1 is hydrogen, amino, or mono- or di- substituted amino, in which the substituent is selected from lower alkyl, acyl and di(lower)alkylaminomethylene, R2 is hydrogen, halogen, lower alkyl or aryl, R3 is ar(lower)alkyl optionally substituted by halogen, A is lower alkylene optionally interrupted by a sulfur atom, and Y is C1 -C3 alkylene, having antiallergic activity.