4036-59-3

Basic information

• Product Name: 2-(2-Benzylidenehydrazino)benzoic acid
• Synonyms: 2-(2-Benzylidenehydrazino)benzoic acid;o-(2-Benzylidenehydrazino)benzoic acid
• CAS NO: 4036-59-3
• Molecular Formula: C₁₄H₁₂N₂O₂
• Molecular Weight: 240.2573
• Mol File: 4036-59-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 425.3°Cat760mmHg
• Flash Point: 211°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 2-(2-Benzylidenehydrazino)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Benzylidenehydrazino)benzoic acid(4036-59-3)
• EPA Substance Registry System: 2-(2-Benzylidenehydrazino)benzoic acid(4036-59-3)

Safety Data

• Hazardous Substances Data: 4036-59-3(Hazardous Substances Data)

Usage

Chemical class

Benzoic acids

Molecular structure

Consists of a benzoic acid molecule with a hydrazine functional group and a benzylidene group attached to one of its benzene rings

Potential applications

Organic synthesis, pharmaceuticals

Possible use

Reagent in chemical reactions, starting material for synthesis of other organic compounds

Additional research needed

To fully understand the potential uses and properties of the compound

InChI:InChI=1/C14H12N2O2/c17-14(18)12-8-4-5-9-13(12)16-15-10-11-6-2-1-3-7-11/h1-10,16H,(H,17,18)/b15-10+

Upstream product

• 56070-95-2 3-benzylideneamino-1,2,3-benzotriazin-4-one 
• 64-17-5 ethanol 
• 150483-54-8 N-benzyl-2-nitrosobenzamide 
• 83412-86-6 C₃₂H₂₅N₂O₂P 
• 1608-42-0 benzenedizolium-2-carboxylate 
• 16721-45-2 triphenyl(phenylmethylene)phosphorane 
• 100-52-7 benzaldehyde 
• 5326-27-2 2-hydrazino-benzoic acid 
• 33906-30-8 2-hydrazinobenzoic acid hydrochloride 
• 10604-20-3 1-benzylideneamino-indole-2,3-dione 
• 7722-84-1 dihydrogen peroxide 
• 1100-88-5 benzyltriphenylphosphonium chloride 
• 52745-10-5 N-(phenylmethyl)-2-nitrobenzamide 

Downstream Products

• 74882-52-3 2-benzylidene-1-(2-methoxycarbonylphenyl)hydrazine 
• 686268-74-6 methyl 2-[2-benzylidene-1-(3-ethoxy-3-oxopropanoyl)hydrazino]benzoate 
• 574757-80-5 2-(N'-benzyl-hydrazino)-benzoic acid 
• 52578-99-1 1,5-Bis-(2-carboxy-phenyl)-3-phenyl-formazan 
• 1848-46-0 2-benzyl-1,2-dihydro-3H-indazol-3-one 
• 686268-88-2 1-(cyclohexylideneamino)-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyguinolin-2(1H)-one 
• 686269-89-6 1-{[(2-bromophenyl)methylene]amino}-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one 
• 686269-83-0 1-{[(3-bromophenyl)methylene]amino}-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one 
• 686269-86-3 1-{[(4-bromophenyl)methylene]amino}-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one 
• 686269-25-0 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-{[1-phenylethylidene]amino}quinolin-2(1H)-one 
• 686269-66-9 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-{[(3-methylphenyl)methylene]amino}quinolin-2(1H)-one 
• 686269-63-6 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-{[(4-methylphenyl)methylene]amino}quinolin-2(1H)-one 
• 686269-69-2 3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-{[(2-methylphenyl)methylene]amino}quinolin-2(1H)-one 
• 850814-42-5 3-(1,1-Dioxo-1,4-dihydro-1λ⁶-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1H-quinolin-2-one 

Relevant articles and documents

Fast alpha nucleophiles: Structures that undergo rapid hydrazone/oxime formation at neutral pH

Hydrazones and oximes are widely useful structures for conjugate formation in chemistry and biology, but their formation can be slow at neutral pH. Kinetics studies were performed for a range of structurally varied hydrazines, and a surprisingly large variation in reaction rate was observed. Structures that undergo especially rapid reactions were identified, enabling reaction rates that rival orthogonal cycloaddition-based conjugation chemistries.

Synthesis and spectral properties of some bis-substituted formazans

Novel, 1,4-bis-[3,3′-phenyl-5,5′-(o-carboxyphenyl)-formaz-1-yl]-benzene-o-sulphonic acid and its derivatives contained {single bond}OH group at the o-, m-, p-positions of the 3-phenyl ring were synthesized. The structures of the formazans were confirmed by elemental analyses, GC-mass, IR, 1H NMR, UV-vis spectra. Their absorption properties were investigated. It was seen that λmax values shifted towards shorter wave lengths by 130 nm in CSPF relative to 1,3,5-triphenylformazan (TPF) due to the fact that the structure of CSPF contained electron withdrawing {single bond}COOH and {single bond}SO3H groups (hypsochromic effect). With binding of {single bond}OH group to 3-phenyl ring of CSPF, it was observed a small bathochromic effect in accordance to the electron donating effect of {single bond}OH group.

Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines

N-1-Alkylamino and N-1-alkyloxy-4-hydroxyquinolon-3-yl benzothiadiazines were synthesized and evaluated as inhibitors of genotype 1 HCV polymerase. The N-1-alkyloxy derivatives were not potent inhibitors, however N-1-alkylamino derivatives displayed compa