40202-09-3 Usage
Description
1,1-Dichloroethane-d4, also known as deuterated 1,1-dichloroethane, is an organic compound that is a derivative of 1,1-dichloroethane with four deuterium atoms replacing four hydrogen atoms. It is a colorless liquid with a chloroform-like odor and is commonly used in various chemical and pharmaceutical applications due to its unique properties.
Uses
Used in Pharmaceutical Industry:
1,1-Dichloroethane-d4 is used as a chemical solvent for the preparation of precursors of quinolizine, isoquinoline, and indole alkaloids. These alkaloids are important in the pharmaceutical industry as they serve as the basis for the synthesis of various drugs with diverse therapeutic applications, such as antiarrhythmic, antihypertensive, and antipsychotic medications.
Used in Chemical Industry:
In the chemical industry, 1,1-Dichloroethane-d4 is utilized as a solvent for various chemical reactions due to its ability to dissolve a wide range of compounds. Its deuterated nature also makes it a valuable tool in studying reaction mechanisms and kinetics, as it can provide insights into the role of hydrogen bonding and other interactions in the reaction process.
Used in Research and Development:
1,1-Dichloroethane-d4 is employed as a research tool in the field of organic chemistry, particularly in the synthesis and study of deuterated compounds. The use of deuterated solvents can help researchers understand the effects of isotopic substitution on reaction rates, equilibria, and other properties, which can be crucial in the development of new drugs and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 40202-09-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,0,2,0 and 2 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 40202-09:
(7*4)+(6*0)+(5*2)+(4*0)+(3*2)+(2*0)+(1*9)=53
53 % 10 = 3
So 40202-09-3 is a valid CAS Registry Number.
40202-09-3Relevant articles and documents
Durig et al.
, p. 3591,3593,3596 (1972)
Photochlorination of Chloroethane and Chloroethane-d5
Tschuikow-Roux, E.,Yano, T.,Niedzielski, J.
, p. 1408 - 1414 (2007/10/02)
The hydrogen/deuterium abstraction from C2H5Cl and C2D5Cl by ground-state chlorine atoms has been investigated between 8 and 94 deg C.Results from the internal competition in chloroethane and chloroethane-d5 combined with the results of external competition with CH4 as the reference reaction have yielded rate constant data for the following reactions: CH3CH2Cl + Cl -> CH3CHCl + HCl, k2s; CH3CH2Cl + Cl -> CH2CH2Cl + HCl, k2p; CD3CD2Cl + Cl -> CD3CDCl + DCl, k2s,D; CD3CDCl + Cl -> CD2CD2Cl + DCl, k2p,D.The temperature dependence of the rate constants (cm3s-1) is given by k2s = (1.43 +/- 0.29) X 1E-11 exp, k2p = (1.35 +/- 0.28) X 1E-11 exp, k2s,D = (0.72 +/- 0.14) X 1E-11 exp , and k2p,D = (0.60 +/- 0.12) X 1E-11 exp.The results confirm the general trend of chlorine atom attack being faster at the substituted carbon atom.Kinetic isotope effects for the abstraction of primary and secondary hydrogen are kH/kD = 5.8 and 2.0 at 298 K, respectively.The magnitude of these relatively weak isotope effects agrees with expectations based on other exothermic chlorination reactions and suggests that in the temperature range of the investigation tunneling does not play an important role.
