401-73-0Relevant articles and documents
A new method for making pyrazole or pyrimidinone
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Paragraph 0298-0301, (2019/11/28)
The invention relates to the use of an amine compound in a method for producing a fluorinated or non-fluorinated 5- or 6-membered heterocyclic compound (preferably pyrazole or pyrimidinone) containingtwo nitrogen atoms in a ring system. The invention also relates to a method for producing a pyrazole or pyrimidinone, which may be fluorinated or may not be fluorinated (non-fluorinated). Each of thefluorinated pyrazole or fluorinated pyrimidinone is a very important structural unit for pharmaceutical and agricultural applications. For example, fungicides are strongly dependent on bifenapram, fluoxastrobin, flubenazolid, fluoxastrobin, pyraclostrobin, and pyracloprid, each with this fluorinated pyrazole as a key structural unit, and benflufenazole respectively, or diflufenacil and chlorfensulfazone (dimethachlor).
Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3- one nucleosides
Abdou, Ibrahim M.,Saleh, Ayman M.,Zohdi, Hussein F.
, p. 109 - 116 (2007/10/03)
2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.
Letter: On the reaction of ethyl 4,4,4-trifluoroacetoacetate with cyanoacetic acid hydrazide--a novel rearrangement of 1-aminopyridine derivatives.
Balicki,Nantka-Namirski
, p. 129 - 131 (2007/10/08)
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