400-74-8 Usage
Description
2-Fluoro-5-nitrobenzotrifluoride is a clear yellowish liquid that is formed during the fluorodenitration of 2-(4-chlorobenzene sulfonyl)-5-nitrotrifluoride using tetramethyl ammonium fluoride. It is a chemical compound with potential applications in various industries due to its unique properties.
Uses
Used in Pharmaceutical Industry:
2-Fluoro-5-nitrobenzotrifluoride is used as a synthetic intermediate for the synthesis of [3-(4-nitro-2-trifluoromethylphenyl)aminophenyl]dihydroxyborane, which can be further utilized in the development of pharmaceutical compounds. Its unique chemical structure allows it to serve as a building block for creating novel molecules with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Fluoro-5-nitrobenzotrifluoride can be employed as a versatile reagent for the creation of various organic compounds. Its fluoro and nitro groups provide opportunities for further functionalization and modification, making it a valuable component in the synthesis of complex molecules.
Used in Research and Development:
Due to its unique properties and potential applications, 2-Fluoro-5-nitrobenzotrifluoride can be used in research and development for exploring new chemical reactions, understanding its reactivity, and identifying novel applications in different industries.
Synthesis Reference(s)
Journal of the American Chemical Society, 78, p. 6034, 1956 DOI: 10.1021/ja01604a022
Check Digit Verification of cas no
The CAS Registry Mumber 400-74-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,0 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 400-74:
(5*4)+(4*0)+(3*0)+(2*7)+(1*4)=38
38 % 10 = 8
So 400-74-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H6FNO3/c1-5(11)6-2-3-7(9)8(4-6)10(12)13/h2-4H,1H3
400-74-8Relevant articles and documents
Fluorodenitration of activated diphenyl sulphones using tetramethylammonium fluoride
Clark, James H.,Wails, David
, p. 201 - 206 (2007/10/02)
Fluorodenitration of nitro-substituted diphenyl sulphones occurs readily in dipolar aprotic solvents using tetramethylammonium fluoride as the source of fluoride, although other reactions including fluorodesulphonylation can sometimes occur in competition. - Keywords: Fluorodenitration; Diphenyl sulphones; Tetramethylammonium fluoride; NMR spectroscopy; Mass spectrometry
A General Procedure for the Fluorodenitration of Aromatic Substrates
Maggini, Michele,Passudetti, Margherita,Gonzales-Trueba, Guadalupe,Prato, Maurizio,Quintily, Ugo,Scorrano, Gianfranco
, p. 6406 - 6411 (2007/10/02)
The synthesis of several fluoroaromatic compounds by a new procedure of fluorodenitration of nitroarenes is reported.The methodology is based on the principle that the nitrite ion, generated during the fluorodenitration processes and responsible for most of the undesired side reactions, can be trapped with a suitable reagent, e.g., phthaloyl difluoride or tetrafluorophthaloyl difluoride.The yields of fluoro compounds thus obtained are good to excellent, and the procedure is of general application.