394222-36-7

Basic information

• Product Name: 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile
• Synonyms: 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile
• CAS NO: 394222-36-7
• Molecular Weight: 480.65
• Mol File: 394222-36-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile(394222-36-7)
• EPA Substance Registry System: 2-(4-(4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butanoyl)phenyl)-2-methylpropanenitrile(394222-36-7)

Safety Data

• Hazardous Substances Data: 394222-36-7(Hazardous Substances Data)

Upstream product

• 129488-73-9 methyl 4-(1-cyano-1-methylethyl)-benzoate 
• 394222-38-9 2-(4-(4-bromobutanoyl)phenyl)-2-methylpropanenitrile 
• 115-46-8 C₁₈H₂₁NO 
• 1252902-28-5 4-(4-(2-cyanopropan-2-yl)phenyl)-4-oxobutyl 4-methylbenzenesulfonate 
• 1308679-43-7 C₁₅H₁₄NO₃^(1-)*Na⁽¹⁺⁾ 
• 394222-37-8 2-(4-(4-hydroxybutanoyl)phenyl)-2-methylpropanenitrile 
• 169032-17-1 2-[4-(4-chloro-butyryl)-phenyl]-2-methyl-propionitrile 
• 76469-88-0 methyl 4-(cyanomethyl)benzoate 
• 169280-06-2 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile 
• 252022-33-6 2-[4-(4-Hydroxy-1-butynyl)phenyl]isobutyronitrile 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 
• 252022-35-8 2-[4-(4-(4-Hydroxydiphenylmethyl-1-piperidyl)-1-butynyl)phenyl]isobutyronitrile 

Downstream Products

• 83799-24-0 fexofenadine 
• 1319714-86-7 fexofenadine sodium salt 
• 138452-21-8 fexofenadine hydrochloride 
• 169032-19-3 2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropionitrile 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN

A new process for the preparation of fexofenadine and of related intermediates, which can be used in the preparation of fexofenadine, is provided.

A new synthesis of carboxyterfenadine (fexofenadine) and its bioisosteric tetrazole analogs

A new synthesis of carboxyterfenadine (4), based on the conversion of a α-halo-alkylarylketone into the corresponding substituted 2-arylalkanoic ester, is described. The enantioselective synthesis of its two bioisosteric tetrazole analogs together with preliminary biological results are reported. Copyright (C) 1999 Elsevier Science S.A.