38873-94-8Relevant articles and documents
Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily
Van Loo, Bert,Bayer, Christopher D.,Fischer, Gerhard,Jonas, Stefanie,Valkov, Eugene,Mohamed, Mark F.,Vorobieva, Anastassia,Dutruel, Celine,Hyv?nen, Marko,Hollfelder, Florian
, p. 370 - 387 (2019)
Highly proficient, promiscuous enzymes can be springboards for functional evolution, able to avoid loss of function during adaptation by their capacity to promote multiple reactions. We employ a systematic comparative study of structure, sequence, and sub
Synthesis and anti-acetylcholinesterase properties of novel β- And γ-substituted alkoxy organophosphonates
Kaleem Ahmed,Belabassi, Yamina,Sankaranarayanan, Lakshmi,Chao, Chih-Kai,Gerdes, John M.,Thompson, Charles M.
, p. 2048 - 2051 (2013/04/23)
Activated organophosphate (OP) insecticides and chemical agents inhibit acetylcholinesterase (AChE) to form OP-AChE adducts. Whereas the structure of the OP correlates with the rate of inhibition, the structure of the OP-AChE adduct influences the rate at