38846-64-9Relevant articles and documents
Selectivity-switchable construction of benzo-fused polycyclic compounds through a gold-catalyzed reaction of enyne-lactone
Luo, Kui,Zhang, Ling,Jiang, Huanfeng,Chen, Lianfen,Zhu, Shifa
, p. 1893 - 1896 (2018)
A gold-catalyzed selectivity-switchable reaction of enyne-lactone is reported. Different products, including naphthalenes and benzo-fused polycyclic compounds, can be selectively obtained from the same starting material. The choice of the gold complex is the key for the chemoselectivity of this system.
Synthesis of Fused Pyrimido[1,6- a ]indolones via Rhodium(III)-Catalyzed Cascade Annulations
Raji Reddy, Chada,Bodasu, Srinivas,Mallesh, Kathe,Prapurna, Y. Lakshmi
, p. 1127 - 1136 (2020/10/29)
A novel method for the synthesis of fused pyrimido[1,6- a ]-indolone derivatives by annulation of 2-alkynylaryl aldehydes/2-alkynyl arylidene ketones with N -(pivaloyloxy)-1 H -indole-1-carboxamide catalyzed by rhodium has been accomplished. The reaction proceeds through C-H activation based annulation with alkyne moiety followed by addition of nitrogen on to aldehyde/activated alkene to give the products in moderate to good yields. Highly fluorescent dipyrrinone analogues could be synthesized from the derived products.
Silver/Rhodium Relay Catalysis Enables C?H Functionalization of In Situ Generated Isoquinolines with Sulfoxonium Ylides: Construction of Hexahydrodibenzo[a,g]quinolizine Scaffolds
Li, Quanzhe,Liu, Ruixing,Wei, Yin,Shi, Min
supporting information, p. 2664 - 2669 (2021/04/05)
Employing silver/rhodium relay catalysis strategy, an intramolecular electrophilic cyclization and C?H activation followed by cascade hydrogenation and reductive amination has been developed. The acylmethylated isoquinoline derivatives could be afforded with broad substrate scope in 23–88% yields, which could be further transformed to the core skeleton of hexahydrodibenzo[a,g]quinolizine as drug-candidates. Moreover, this reaction was achieved in a gram-scale. A reasonable reaction mechanism has been proposed based on a series of control and KIE experiments. (Figure presented.).
Au(I)/(R)-BINOL-Ti(IV) concerted catalyzed asymmetric cascade cycloaddition reaction of arylalkynols
Wang, Hongkai,Zeng, Tianlong,Chang, Weixing,Liu, Lingyan,Li, Jing
supporting information, p. 3573 - 3577 (2021/05/31)
An efficient catalytic asymmetric cascade cycloaddition reaction of arylalkynols with dioxopyrrolidines was developed. This reaction was achieved using Au(I) and (R)-BINOL-Ti(IV) bimetallic catalysts and exclusively delivered a series of chiral oxo-bridged bicyclic benzooxacine compounds in up to 86% yield with 96% ee as well as >33:1 dr. Meanwhile, three new σ bonds and three new stereogenic centers were formed in a one-pot process.
