38763-29-0 Usage
Description
Worenine is a quaternary alkaloid found in Coptis japonica, which has been isolated as the tetrahydro base. It forms colorless prisms from ethanol with a melting point of 212-213°C and can be oxidized by iodine in ethanol to form worenine iodide. The iodide forms yellow crystals, and the corresponding chloride can be obtained as orange-yellow prisms with a melting point of 295°C (decomposes).
Uses
Used in Flurophore Switched Probes:
Worenine is used as a flurophore switched probe for the correction of an abasic site (AP site) caused by the removal of a damaged base in DNA. This application aids in the detection and repair of DNA damage, which is crucial for maintaining genetic stability and preventing mutations.
References
Kitasato., J. Pharm. Soc., Japan, No. 542, 48 (1927)
Kitasato., Acta Phytochimica, 3,210 (1927)
Check Digit Verification of cas no
The CAS Registry Mumber 38763-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,7,6 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 38763-29:
(7*3)+(6*8)+(5*7)+(4*6)+(3*3)+(2*2)+(1*9)=150
150 % 10 = 0
So 38763-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H16NO4/c1-11-14-6-18-17(23-10-24-18)5-13(14)8-21-3-2-12-4-16-19(25-9-22-16)7-15(12)20(11)21/h4-8H,2-3,9-10H2,1H3/q+1
38763-29-0Relevant articles and documents
A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps
Zhou, Shiqiang,Tong, Rongbiao
supporting information, p. 7084 - 7089 (2016/05/19)
A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A3 reaction, Pd-catalyzed reductive carbocyclization, and PtO2-catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids.
