387353-77-7

Basic information

• Product Name: Aliskiren inter-11
• Synonyms: Aliskiren inter-11;Methyl (2S,4E)-5-chloro-2-isopropylpent-4-enoate;(2S,4E)-5-Chloro-2-tert-butyl-4-pentenoic acid Methyl ester;(S,E)-Methyl 5-chloro-2-isopropylpent-4-enoate
• CAS NO: 387353-77-7
• Molecular Formula: C₉H₁₅ClO₂
• Molecular Weight: 190.67
• Product Categories: aliskiren
• Mol File: 387353-77-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 203 ºC
• Flash Point: 77 ºC
• Appearance: /
• Density: 1.023
• Vapor Pressure: 0.28mmHg at 25°C
• Refractive Index: 1.453
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Aliskiren inter-11(CAS DataBase Reference)
• NIST Chemistry Reference: Aliskiren inter-11(387353-77-7)
• EPA Substance Registry System: Aliskiren inter-11(387353-77-7)

Safety Data

• Hazardous Substances Data: 387353-77-7(Hazardous Substances Data)

Usage

General Description

Aliskiren inter-11 is a chemical compound that belongs to the class of aliskiren-based inhibitors. It acts as a direct renin inhibitor, blocking the activity of the enzyme renin which is involved in the production of angiotensin II, a hormone that regulates blood pressure and fluid balance. By inhibiting renin, aliskiren inter-11 helps to lower blood pressure and improve kidney function, making it useful in the treatment of hypertension and chronic kidney disease. Additionally, it also has potential applications in heart failure and diabetes management. Its mechanism of action differs from other antihypertensive drugs, making it a valuable option for patients who do not respond well to other medications. Further research and clinical trials are ongoing to explore the full therapeutic potential and specific indications of aliskiren inter-11.

InChI:InChI=1/C9H15ClO2/c1-7(2)8(5-4-6-10)9(11)12-3/h4,6-8H,5H2,1-3H3/b6-4+/t8-/m0/s1

Upstream product

• 475562-17-5 methyl (4E)-5-chloro-2-isopropyl-4-pentenoate 
• 51122-91-9 dimethyl isopropylmalonate 
• 705259-97-8 dimethyl 2-[(2E)-3-chloro-2-propenyl]-2-isopropyl malonate 
• 72651-95-7 5-isopropyl-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 67-56-1 methanol 
• 324519-66-6 (S)-(4E)-5-chloro-2-isopropyl-4-pentenoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 87953-16-0 (4E)-5-chloro-2-isopropyl-4-pentenoic acid 
• 1350705-33-7 (S,E)-5-chloro-2-isopropyl pent-4-enoic acid phenyl ethanamine 

Downstream Products

• 387353-71-1 (2S,7R,E)-methyl 2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnon-4-enoate 
• 393108-57-1 (3S,5S)-5-{(1R,3S)-1-bromo-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 324763-47-5 (2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide 
• 325154-26-5 (2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-N,N,8-trimethylnon-4-enamide 
• 1350705-30-4 (2S,7R,E)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methyl non-4-enoic acid tert-butylamine 
• 325740-70-3 (3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 
• 324519-68-8 trans-(2S)-5-chloro-2-isopropyl-N,N-dimethyl-4-pentenamide 
• 900811-48-5 (S)-5-((S)-1-amino-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 
• 866030-35-5 tert-butyl {(1S,3S)-1-((2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl}carbamate 

Relevant articles and documents

PROCESS FOR PREPARING ALISKIREN AND ITS INTERMEDIATES

The present application relates to a process for the preparation of aliskiren and its pharmaceutically acceptable salts. In particular, the present application relates to a process for the preparation of intermediates for aliskiren, and their conversion to aliskiren or its salts.

METHOD FOR PRODUCING OPTICALLY ACTIVE (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ACID OR BASIC AMINO ACID SALT THEREOF

To provide a method for producing an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid, a basic amino acid salt thereof or an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid ester with high yield and high optical purity by simple operation. An optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid is obtained by precipitating a basic amino acid salt of optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid from a solvent solution containing an optical isomer mixture of (4E)-5-chloro-2-isopropyl-4-pentenoic acid and an optically active basic amino acid or a salt thereof, and then the basic amino acid salt of optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid is subjected to a desalting reaction. Further, an esterification reaction is carried out to obtain an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid ester.

METHOD FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOATE AND OPTICALLY ACTIVE SUBSTANCE THEREOF

To provide a process for producing a (4E)-5-chloro-2-isopropyl-4-pentenoate in high yield and efficiently. A compound (2) is reacted with a base in the presence of an aprotic solvent and then with (1E)-1,3-dichloro-1-propene in the same reaction vessel to obtain a compound (3), and then either of -COOR moieties in the compound (3) is replaced with a hydrogen atom in the same reaction vessel to obtain a compound (4): wherein R is a lower alkyl group or an aralkyl group.