38496-18-3

Basic information

• Product Name: 2,6-Dichloronicotinic acid
• Synonyms: 2,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID;2,6-DICHLORONICOTINIC ACID;2,6-DICHLORONICOTININC ACID;2,6-DICHLORO-3-PYRIDINECARBOXYLIC ACID;TIMTEC-BB SBB003625;2 6-DICHLORONICOTINIC ACID TECH. 90%;2,6-Dichloronicotinic;2,6-DICHLOROCOTINIC ACID
• CAS NO: 38496-18-3
• Molecular Formula: C₆H₃Cl₂NO₂
• Molecular Weight: 192
• EINECS: -0
• Product Categories: pyridine derivative;Acids and Derivatives;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Carboxylic Acids;Pyridines;Pyridine;Organic acids;Pyridines derivates;Heterocyclic Compounds;Chloropyridines;Halopyridines;Inhibitors;Nicotine Derivatives;Carboxylic Acids;Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;alkyl chloride|carboxylic acid
• Mol File: 38496-18-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 140-143 °C(lit.)
• Boiling Point: 351.2 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: Off-white or pale yellow/Crystalline Powder
• Density: 1.612 g/cm³
• Vapor Pressure: 1.56E-05mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: DMSO, Methanol
• PKA: 1.77±0.28(Predicted)
• BRN: 136114
• CAS DataBase Reference: 2,6-Dichloronicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloronicotinic acid(38496-18-3)
• EPA Substance Registry System: 2,6-Dichloronicotinic acid(38496-18-3)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 38496-18-3(Hazardous Substances Data)

Usage

Description

2,6-Dichloronicotinic acid is an organic compound characterized by the presence of two chlorine atoms at the 2nd and 6th positions on a pyridine ring. It serves as a key intermediate in the synthesis of various chemical compounds and pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
2,6-Dichloronicotinic acid is used as a precursor for the preparation of pyridine derivatives, which act as inhibitors of the human 11β hydroxysteroid dehydrogenase type 1 enzyme. This enzyme plays a crucial role in the regulation of glucocorticoid hormones, and its inhibition can have therapeutic benefits in treating various diseases related to hormonal imbalances and inflammation.

InChI:InChI=1/C6H3Cl2NO2/c7-4-2-1-3(6(10)11)5(8)9-4/h1-2H,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 55366-30-8 2,6-dichloro-3-(trichloromethyl)pyridine 
• 2402-78-0 2,6-dichloropyridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 562106-19-8 6-chloro-2-[2-(4-methoxyphenyl)-2-oxo-ethyl]-nicotinic acid 
• 453561-75-6 N-(3,4-dichlorophenyl) {6-[(2-morpholin-4-ylethyl)-amino]-2-[(4-pyridylmethyl)-amino] (3-pyridyl)}-carboxamide 
• 862170-58-9 (2,6-dichloro-3-pyridinyl)(4-fluorophenyl)methanone 
• 862170-53-4 (2,6-dichloro-3-pyridinyl)[4-(methyloxy)phenyl]methanone 
• 1308917-77-2 (4-{7-Amino-8-ethyl-5-oxo-6-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-5,8-dihydro-[1,8]naphthyridin-2-yl}-phenyl)-acetic acid 
• 1308917-80-7 2-{4-[7-amino-8-ethyl-5-oxo-6-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-5,8-dihydro-1,8-naphthyridin-2-yl]phenyl}-N-[(4-cyclopropylmorpholin-3-yl)methyl]acetamide 
• 1308917-78-3 C₂₉H₃₇N₅O₄Si 
• 1314069-32-3 2-amino-7-(4-{[(2,3-dichlorophenyl)sulfonyl]amino}-3-fluorophenyl)-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide 
• 55304-90-0 2,6-dichloro-3-(hydroxymethyl)pyridine 
• 58584-86-4 ethyl 2,6-dichloronicotinate 
• 58584-92-2 2-amino-6-chloronicotinic acid 
• 873936-98-2 Ro 4808591 
• 372117-97-0 2-chloro-5-carboxy-6-(3-chloro-4-methoxybenzylamino)pyridine 
• 1026821-96-4 2-[(2,4-dimethoxybenzyl)thio]-6-methylamino-N-(4-pyridinyl)pyridine-3-carboxamide 

Relevant articles and documents

A convenient synthesis of [2,6-14C]-2-chloroisonicotinic acid

[2,6-14C]-2-chloroisonicotinic acid (1) was prepared by kinetically controlled lithiation and carbonation of [2,6-14C]-2,6-dichloropyridine, followed by reduction using hydrazine and potassium hydroxide. Copyright