380238-10-8

Basic information

• Product Name: 3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE
• Synonyms: 5-METHYL-2-(2-TRIFLUOROMETHYL-PHENYL)-2H-PYRAZOL-3-YLAMINE;AKOS BBS-00006677;3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE;5-Amino-3-methyl-1-[2-(trifluoromethyl)phenyl]-1H-pyrazole, 2-(5-Amino-3-methyl-1H-pyrazol-1-yl)benzotrifluoride
• CAS NO: 380238-10-8
• Molecular Formula: C₁₁H₁₀F₃N₃
• Molecular Weight: 241.21
• EINECS: 200-258-5
• Mol File: 380238-10-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 342.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.37±0.10(Predicted)
• CAS DataBase Reference: 3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE(380238-10-8)
• EPA Substance Registry System: 3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE(380238-10-8)

Safety Data

• Hazardous Substances Data: 380238-10-8(Hazardous Substances Data)

Usage

Description

3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE is a pyrazole derivative chemical compound with the molecular formula C11H10F3N3. It features a trifluoromethylphenyl group and a methyl group, and is of interest in pharmaceutical research and development for its potential use in the synthesis of new drug candidates or as a building block for other bioactive molecules.

Uses

Used in Pharmaceutical Research and Development:
3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE is used as a chemical intermediate for the synthesis of new drug candidates due to its unique structural features and potential bioactivity.
Used in the Creation of Bioactive Molecules:
In the field of medicinal chemistry, 3-METHYL-1-[2-(TRIFLUOROMETHYL)PHENYL]-1H-PYRAZOL-5-AMINE serves as a building block for the development of bioactive molecules, which may have therapeutic applications.

Upstream product

• 2469-99-0 Cyanoaceton 
• 365-34-4 2-(trifluoromethyl)phenylhydrazine 
• 1118-61-2 3-Aminocrotononitrile 

Downstream Products

• 1380573-47-6 4-(4-phenoxyphenyl)-3,6-dimethyl-1-(2-trifluoromethylphenyl)-4,8-dihydro-1H-pyrazolo[3,4-e][1,4]thiazepin-7-one 

Relevant articles and documents

Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M

The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction of defective in cullin neddylation 1 (DCN1), a CRL neddylation co-E3, and UBE2M, a neddylation E2. Our first-generation inhibitors possessed poor oral bioavailability and fairly rapid clearance that hindered the study of acute inhibition of DCN-controlled CRL activity in vivo. Herein, we report studies to improve the pharmacokinetic performance of the pyrazolo-pyridone inhibitors. The current best inhibitor, 40, inhibits the interaction of DCN1 and UBE2M, blocks NEDD8 transfer in biochemical assays, thermally stabilizes cellular DCN1, and inhibits anchorage-independent growth in a DCN1 amplified squamous cell carcinoma cell line. Additionally, we demonstrate that a single oral 50 mg/kg dose sustains plasma exposures above the biochemical IC90 for 24 h in mice.

SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF

The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.