37496-06-3

Basic information

• Product Name: (1-methyl-1H-pyrrol-2-yl)(phenyl)methanone
• Synonyms: Methanone, (1-methyl-1H-pyrrol-2-yl)phenyl-
• CAS NO: 37496-06-3
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.2218
• Mol File: 37496-06-3.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Density: 1.05g/cm³
• Vapor Pressure: 0.000536mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: (1-methyl-1H-pyrrol-2-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1-methyl-1H-pyrrol-2-yl)(phenyl)methanone(37496-06-3)
• EPA Substance Registry System: (1-methyl-1H-pyrrol-2-yl)(phenyl)methanone(37496-06-3)

Safety Data

• Hazardous Substances Data: 37496-06-3(Hazardous Substances Data)

Usage

General Description

(1-methyl-1H-pyrrol-2-yl)(phenyl)methanone, also known as 1-Methyl-2-pyrrolidinone, is a chemical compound with the molecular formula C13H13NO. It is a pale yellow to amber liquid that is commonly used as a solvent in various industrial applications such as petrochemical processing, pharmaceutical manufacturing, and agrochemical production. It is also used as a reactant and intermediate in organic synthesis. (1-methyl-1H-pyrrol-2-yl)(phenyl)methanone is known for its high solvency, low vapor pressure, and thermal stability, making it a versatile and valuable chemical in various processes. However, it is important to handle this chemical with care as it may pose health hazards and environmental risks if not properly managed.

Upstream product

• 112925-40-3 1-Methyl-2-(2-phenyl-benzo[1,3]oxathiol-2-yl)-1H-pyrrole 
• 96-54-8 N-Methylpyrrole 
• 98-86-2 acetophenone 
• 611-73-4 Benzoylformic acid 
• 7697-46-3 phenyl(1H-pyrrol-2-yl)methanone 
• 373-68-2 tetramethylammonium fluoride 
• 1119-97-7 cetyltrimethylammonium bromide 
• 10181-59-6 2,2,4,4-tetramethyl-3-thioxocyclobutanone 
• 89444-67-7 (N-methylpyrrol-2-yl)(phenyl)methanethione 
• 100-47-0 benzonitrile 
• 58948-35-9 2-phenyl-1,3-benzoxathiolium tetrafluoroborate 
• 80965-03-3 2-(methylsulfonyl)-5-benzoylpyrrole 
• 611-74-5 N,N-dimethylbenzamide 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 161560-66-3 2-benzoyl-1-methyl-1H-pyrrole-4-carboxaldehyde 
• 676599-93-2 2-benzoyl-1-methyl-1H-pyrrole-5-carboxaldehyde 
• 112064-28-5 cyclopropyl(1-methyl-2-pyrrolyl)phenylmethanol 
• 560088-45-1 (5-Benzoyl-1-methyl-1H-pyrrol-3-yl)-pyridin-4-ylmethanone 
• 161561-03-1 (5-Benzyl-1,3-dimethyl-1H-pyrrol-2-yl)-acetic acid ethyl ester 
• 161560-67-4 2-benzyl-1,4-dimethylpyrrole 
• 89444-67-7 (N-methylpyrrol-2-yl)(phenyl)methanethione 
• 62128-30-7 (1-methyl-1H-pyrrol-3-yl)(phenyl)methanone 
• 52293-26-2 phenyl(N-methyl-2-pyrrolyl)carbinol 

Relevant articles and documents

Aroylation of Electron-Rich Pyrroles under Minisci Reaction Conditions

The development of Minisci acylation on electron-rich pyrroles under silver-free neutral conditions has been reported featuring the regioselective monoacylation of (NH)-free pyrroles. Unlike conventional Minisci conditions, the avoidance of any acid that could result in the polymerization of pyrroles was the key to success. The umpolung reactivity of the nucleophilic acyl radical, generated in situ from arylglyoxylic acid, could help explain the mechanism of product formation with electron-rich pyrroles. Alternatively, the nucleophilic substitution of the acyl radical on the electron-deficient pyrrole radical cation is proposed.

A Novel and Chemoselective Process of N -Alkylation of Aromatic Nitrogen Compounds Using Quaternary Ammonium Salts as Starting Material

The process of N-alkylation of several pyrroles, indoles, and derivative heterocycles is herein described, using quaternary ammonium salts as the source of an alkylating agent. These reactions were carried out on several heterocyclic rings with triethylbenzylammonium chloride or tetradecyltrimethylammonium bromide and an NaOH solution at 50%, leading to a chemoselective N-alkylated product and an average yield of 73%. This is an alternative process to the traditional benzylation and methylation of N-heterocycles with direct handling of alkyl halides.

Acylation of pyrroles and their free (N-H)-derivatives via palladium-catalyzed carbopalladation of nitriles

An efficient regioselective synthesis of 2-acylpyrroles via palladium-catalyzed addition of pyrroles with benzonitriles and subsequent hydrolysis is developed. The direct acylation reaction of protected as well as (NH)-free pyrroles proceeded smoothly to