37259-53-3 Usage
Description
Hyaluronidase, also known as hyaluronate 4-glucohydrolase or spreading factor, is an enzyme that breaks down hyaluronic acid, a component of the extracellular matrix, in living tissues. It is widely present in nature and can be found in various organisms, including humans, where it is present in several organs and body fluids. Hyaluronidase is also found in the secretions of various microorganisms, such as viruses, bacteriophages, fungi, and bacteria, as well as in the venom of snakes and scorpions, and the secretions of bees, spiders, wasps, hornets, caterpillars, fishes, and lizards.
Uses
Used in Cell Culture Applications:
Hyaluronidase is used as an enzyme in the preparation of DMEM/F-12 (Dulbecco's modified eagle medium/nutrient mixture F-12) media for the isolation and purification of single cells from dissociated tumor tissue. It aids in the dispersion and attachment of cells, facilitating their growth and proliferation in vitro.
Used in Stem Cell Research:
Hyaluronidase is used as a component of the digestion solution for the derivation of germline stem cells from testicular tissue. It helps in breaking down the hyaluronic acid present in the extracellular matrix, allowing for the efficient isolation and extraction of stem cells for further research and potential therapeutic applications.
Used in Pharmaceutical Industry:
Hyaluronidase is used as an adjuvant in the pharmaceutical industry to enhance the absorption and distribution of various drugs, particularly those administered through injection. Its ability to break down hyaluronic acid in tissues increases the permeability of the administered area, allowing for faster and more efficient drug delivery.
Used in Diagnostic Procedures:
Hyaluronidase is used as an enzyme in certain diagnostic procedures, such as the detection of hyaluronic acid in biological samples. Its specificity for hyaluronic acid makes it a valuable tool for identifying and quantifying this molecule in various research and clinical applications.
Used in Veterinary Medicine:
Hyaluronidase is used in veterinary medicine as an aid in the treatment of various conditions, such as inflammation and edema, by facilitating the dispersion and absorption of fluids in the affected tissues. Its ability to break down hyaluronic acid can help reduce swelling and promote healing in animals.
Biochem/physiol Actions
Hyaluronate lyase degrades hyaluronate using an elimination reaction to break glycosidic linkages yielding unsaturated disaccharide products. It is important for the diffusion of toxins and proteins produced by S. pyogenes.
Check Digit Verification of cas no
The CAS Registry Mumber 37259-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,2,5 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 37259-53:
(7*3)+(6*7)+(5*2)+(4*5)+(3*9)+(2*5)+(1*3)=133
133 % 10 = 3
So 37259-53-3 is a valid CAS Registry Number.
