37231-28-0

Basic information

• Product Name: MELITTIN
• Synonyms: melittinfrombeevenomsequencing*grade;melittinhoneybeevenom;melittin-t;MELLITIN;MELITTIN;MELITTIN (NATURAL);GIGAVLKVLTTGLPALISWIKRKRQQ-NH2;H-GLY-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-THR-THR-GLY-LEU-PRO-ALA-LEU-ILE-SER-TRP-ILE-LYS-ARG-LYS-ARG-GLN-GLN-NH2
• CAS NO: 37231-28-0
• Molecular Formula: C131H229N39O31
• Molecular Weight: 2846.46
• EINECS: 253-417-7
• Product Categories: Protein Sequencing;Protein Structural Analysis;Standards for Protein Sequencing;Chelators;Enzyme Inhibitors;Enzyme Inhibitors by Type;Calcium AntagonistsEnzyme Inhibitors by Enzyme;Protein kinase CEnzymes, Inhibitors, and Substrates;Cell Signaling and Neuroscience;Intracellular Calcium Signaling;P to;Protein Kinase Inhibitors and Related Products;Protein Kinases and Phosphatases
• Mol File: 37231-28-0.mol
• Article Data: 0

Chemical Properties

• Flash Point: 112 °C
• Appearance: solid
• Storage Temp.: 2-8°C
• Solubility: Water (Slightly)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 13,5846
• CAS DataBase Reference: MELITTIN(CAS DataBase Reference)
• NIST Chemistry Reference: MELITTIN(37231-28-0)
• EPA Substance Registry System: MELITTIN(37231-28-0)

Safety Data

• Hazard Codes: T,Xn
• Statements: 23/24/25-21/22
• Safety Statements: 36
• RIDADR: UN 3462 6.1/PG 1
• WGK Germany: 3
• RTECS: OS3965000
• F: 10-21
• Hazardous Substances Data: 37231-28-0(Hazardous Substances Data)

Usage

Description

Melittin is a 26-amino acid peptide found in bee venom that possesses a variety of biological activities, including anti-inflammatory, antimicrobial, and anticancer properties. It has the ability to modulate immune responses and induce apoptosis in cancer cells, making it a promising candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
Melittin is used as an antirheumatic drug for its anti-inflammatory properties, helping to alleviate the symptoms of rheumatoid arthritis and other inflammatory conditions.
Used in Cancer Therapy:
Melittin is used as an apoptosis inducer, NF-κB inhibitor, and PLA2 activator in cancer therapy. Its ability to induce apoptosis in cancer cells and inhibit the NF-κB signaling pathway, which is often dysregulated in cancer cells, makes it a potential therapeutic agent for various types of cancer.
Used in MelittinTrifluoroacetic Acid Salt:
MelittinTrifluoroacetic Acid Salt is a modified version of Melittin that retains its apoptotic, NF-κB inhibitory, and PLA2 activating properties. This form of Melittin may offer improved stability and bioavailability, enhancing its therapeutic potential in various applications.

InChI:InChI=1/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,