37167-62-7Relevant articles and documents
MALIC ENZYME INHIBITORS
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Page/Page column 119, (2021/04/23)
The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
Manganese/bipyridine-catalyzed non-directed C(sp3)–H bromination using NBS and TMSN3
Sneh, Kumar,Torigoe, Takeru,Kuninobu, Yoichiro
supporting information, p. 885 - 890 (2021/05/05)
A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp3)?H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups.
Activating ATRP Initiators to Incorporate End-Group Modularity into Photo-RAFT Polymerization
Hakobyan, Karen,McErlean, Christopher S. P.,Müllner, Markus
, p. 10357 - 10365 (2020/12/23)
Heterogeneous photocatalysis is increasingly used in reversible deactivation radical polymerization (RDRP). In this study, we found that alkyl bromide redox chemistry typically found in atom transfer radical polymerization (ATRP) can be incorporated in concert with dithiocarbonyl disulfide chemistry into the reversible addition-fragmentation chain transfer (RAFT) process via bismuth oxide photocatalysis. This amalgamation of mechanisms introduces end-group modularity - a new layer of control - into RAFT polymers uniquely enabled by photoredox catalysis. We found that a diversity of functionality can be installed at the α-end group via alkyl bromides, while the molecular weight distribution can be tuned seamlessly at the ω-end group through the simultaneous addition of multiple disulfides.