37159-97-0

Basic information

• Product Name: L-PROLINE-(4-3H(N))
• Synonyms: L-PROLINE-(4-3H(N));CL061
• CAS NO: 37159-97-0
• Molecular Formula: C5H9NO2
• Molecular Weight: 115.13046
• Mol File: 37159-97-0.mol
• Article Data: 337

Chemical Properties

• Boiling Point: 252.187 °C at 760 mmHg
• Flash Point: 106.319 °C
• Appearance: /aqueous ethanol solution
• Density: 1.186 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: L-PROLINE-(4-3H(N))(CAS DataBase Reference)
• NIST Chemistry Reference: L-PROLINE-(4-3H(N))(37159-97-0)
• EPA Substance Registry System: L-PROLINE-(4-3H(N))(37159-97-0)

Safety Data

• Hazard Codes: R
• RIDADR: UN 2910 7
• WGK Germany: 3
• Hazardous Substances Data: 37159-97-0(Hazardous Substances Data)

Usage

General Description

L-PROLINE-(4-3H(N)) is a radiolabeled form of the amino acid L-proline, which contains a tritium atom (^3H) at the 4 position of the nitrogen atom. This radiolabeled compound is used in biochemical and pharmacological research to track the metabolism and distribution of proline in biological systems. Tritium-labeled compounds are useful for studying the behavior of specific molecules in living organisms, as the radioactive tritium atoms can be detected and measured using various techniques, such as scintillation counting. L-PROLINE-(4-3H(N)) can provide valuable insights into proline metabolism, protein synthesis, and other cellular processes.

InChI:InChI=1/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1

Upstream product

• 41419-12-9 3,3-dichloro-piperidin-2-one 
• 6829-40-9 aminomalonic acid diethyl ester 
• 21761-19-3 (+/-)-5-amino-2-chloro-valeric acid 
• 617-65-2 Glutamic acid 
• 857975-85-0 5-amino-2,2-dichloro-valeric acid 
• 15647-47-9 5-benzoylaminopentanoic acid 
• 6326-44-9 diethyl 2-formylaminomalonate 
• 109-70-6 1.3-chlorobromopropane 
• 109-64-8 1,3-dibromo-propane 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 36901-87-8 trans-hydroxyproline 
• 151-50-8 potassium cyanide 
• 117614-91-2 ethyl N-acetyl-O-p-toluenesulfonyl-2-amino-2-ethoxycarbonyl-5-hydroxypentanoate 
• 147-85-3 L-proline 

Downstream Products

• 119910-72-4 1,2,3,3aα,4β,6,7,8,8aα,8bα-decahydro-2-phenyl-4-(2-pyridyl)pyrrolo<3,4-a>pyrrolizine-1,3-dione 
• 119910-72-4 1,2,3,3aα,4α,6,7,8,8aβ,8bα-decahydro-2-phenyl-4-(2-pyridyl)pyrrolo<3,4-a>pyrrolizine-1,3-dione 
• 18877-34-4 1,2,3,11a-tetrahydro-10H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11-dione 
• 7364-47-8 TMS-DL-Pro-OTMS 
• 137441-49-7 C₂₅H₃₄N₂O₃ 
• 73004-43-0 N-Carbethoxy-prolin 
• 108286-48-2 3-Methyl-1-phenyl-6,7-dihydro-5H-pyrrolizine-2-carbonitrile 
• 108286-45-9 3-Methyl-2-phenyl-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid methyl ester 
• 108286-44-8 3-Methyl-1-phenyl-6,7-dihydro-5H-pyrrolizine-2-carboxylic acid methyl ester 
• 1074-79-9 N-Acetyl-DL-prolin 
• 103847-61-6 (2R,3S,7aR)-2,3-Bis-(4-nitro-phenyl)-hexahydro-pyrrolo[2,1-b]oxazole 
• 103847-61-6 (2S,3S,7aR)-2,3-Bis-(4-nitro-phenyl)-hexahydro-pyrrolo[2,1-b]oxazole 
• 80514-78-9 Trit-Pro-OH.Et2NH 
• 84969-62-0 Sodium; 1-(4-chloro-phenyl-diazenyl)-pyrrolidine-2-carboxylate 

Relevant articles and documents

Squamins C–F, four cyclopeptides from the seeds of Annona globiflora

Four cyclic octapeptides, squamins C–F, were isolated from the seeds of Annona globiflora Schltdl. These compounds share part of their amino acid sequence, -Pro-Met(O)-Tyr-Gly-Thr-, with previously reported squamins A and B. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR), ESI-HRMS data and a modified version of Marfey's chromatographic method. All compounds showed cytotoxic activity against DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines. Clearly, A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie.

Direct monitoring of biocatalytic deacetylation of amino acid substrates by1H NMR reveals fine details of substrate specificity

Amino acids are key synthetic building blocks that can be prepared in an enantiopure form by biocatalytic methods. We show that thel-selective ornithine deacetylase ArgE catalyses hydrolysis of a wide-range ofN-acyl-amino acid substrates. This activity was revealed by1H NMR spectroscopy that monitored the appearance of the well resolved signal of the acetate product. Furthermore, the assay was used to probe the subtle structural selectivity of the biocatalyst using a substrate that could adopt different rotameric conformations.

Irreversible inhibitors of the proline racemase unveil innovative mechanism of action as antibacterial agents against Clostridioides difficile

Proline racemases (PRAC), catalyzing the l-proline and d-proline interconversion, are essential factors in eukaryotic pathogens such as Trypanosoma cruzi, Trypanosoma vivax, and Clostridioides difficile. If the discovery of irreversible inhibitors of T.?cruzi PRAC (TcPRAC) led to innovative therapy of the Chagas disease, no inhibitors of CdPRAC have been discovered to date. However, C.?difficile, due to an increased incidence in recent years, is considered as a major cause of health threat. In this work, we have taken into account the similarity between TcPRAC and CdPRAC enzymes to design new inhibitors of CdPRAC. Starting from (E) 4-oxopent-2-enoic acid TcPRAC irreversible inhibitors, we synthesized 4-aryl substituted analogs and evaluated their CdPRAC enzymatic inhibition against eleven strains of C.?difficile. This study resulted in promising candidates and allowed for identification of (E)-4-(3-bromothiophen-2-yl)-4-oxobut-2-enoic acid 20 that was chosen for complementary in vivo studies and did not reveal in vivo toxicity.