37128-50-0 Usage
Description
(2-methyl-1H-indol-3-yl)(pyridin-3-yl)methanone, also known as MI-503, is a small molecule inhibitor that targets the activity of the transcriptional coactivators p300/CBP. It is a promising pharmaceutical candidate with potential anticancer effects, particularly in the treatment of various types of solid tumors.
Used in Oncology:
(2-methyl-1H-indol-3-yl)(pyridin-3-yl)methanone is used as an anticancer agent for the treatment of various types of solid tumors, such as lung, breast, and colon cancer. It works by inhibiting the interaction between p300/CBP and the transcription factor MYC, leading to the suppression of MYC-dependent gene expression and the induction of tumor cell death.
Additionally, (2-methyl-1H-indol-3-yl)(pyridin-3-yl)methanone demonstrates synergistic anticancer effects when combined with other anticancer agents, enhancing the overall efficacy of cancer therapies and making it a promising candidate for future cancer treatment strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 37128-50-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,1,2 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37128-50:
(7*3)+(6*7)+(5*1)+(4*2)+(3*8)+(2*5)+(1*0)=110
110 % 10 = 0
So 37128-50-0 is a valid CAS Registry Number.
37128-50-0Relevant articles and documents
Elucidation of the conformational properties of 3-pyridinoyl indoles as intermediates of cannabimimetics
Araki, Koji,Tabata, Hidetsugu,Makino, Kosho,Ujiie, Ryohei,Sezaki, Kohei,Nakayama, Hiroshi,Oshitari, Tetsuta,Natsugari, Hideaki,Takahashi, Hideyo
, p. 1423 - 1435 (2019/12/23)
The conformations of 3-pyridinoyl indoles, which are intermediates of 5-fluoropentyl-3-pyridinoyl indole, were investigated using their X-ray crystal structures. All derivatives existed as s-trans conformers. A pseudo-planar conformation was observed in the 2'-yl isomer of 3-pyridinoyl indoles. On the other hand, twisted conformations were observed in 3-pyridinoyl 2-methylindoles. The conformations of these compounds in solution were also investigated using VT-NMR.