371242-69-2 Usage
Description
2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone is a member of the quinazoline class, specifically a quinazolin-4(3H)-one derivative. It features a (6-amino-9H-purin-9-yl)methyl group at position 2, a 2-methylphenyl group at position 3, and a methyl substituent at position 5. 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone has potential applications in various fields due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone is used as a pharmaceutical compound for its potential therapeutic effects. The presence of the purine and quinazoline moieties suggests that it may have biological activity, possibly as an inhibitor or modulator of certain enzymes or receptors, which could be useful in the development of drugs for various diseases.
Used in Research and Development:
In the field of research and development, 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone can be used as a starting material or a tool compound to study the structure-activity relationships of quinazoline-based drugs. Its synthesis and modification can provide insights into the design of new drugs with improved potency, selectivity, and pharmacokinetic properties.
Used in Chemical Synthesis:
As a member of the quinazoline class, 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone can be employed as an intermediate in the synthesis of more complex molecules. Its unique functional groups and substitution patterns make it a valuable building block for the creation of novel chemical entities with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
In vitro
IC-87114 selectively inhibits PI3Kδ and not sensitive to PI3Kα, β, and γ. In human neutrophils, IC87114 (5 μM) potently inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated phosphatidylinositol triphosphate (PIP3) biosynthesis and chemotaxis. IC87114 (5 μM) also inhibits polarized morphology and spreading of neutrophils. In human acute myeloid leukemia (AML) blast cells, such as bone marrow mononuclear cells (BMMCs), IC87114 (10 μM) inhibits both constitutive and Flt-3-stimulated Akt phosphorylation and cell proliferation. It is also found that IC87114 (5 μM–30 μM) inhibits SCF-or IL-3-stimulated BMMC responses, which are not observed in PI3Kδ mutant (p110δD910A) cells. In anti-CD3-stimulated mice CD62L+ (naive) and CD62L? (effector/memory) CD4+ T cells, IC87114 inhibits proliferation and interferon-gamma (IFN-γ) production. The IC50 values of IC87114 are: (1) 1.2 μM and 40 nM, for CD62L+ and CD62L? cell proliferation, respectively; (2) 120 nM and 1 nM, for IFN-γ production of CD62L+ and CD62L? cells, respectively. Similar effects by IC87114 are also observed in human T cells. A recent study reveals that in chromaffin cells, IC87114 enhances the transient increase of PtdIns(4,5)P2, which results in a potentiation of exocytosis.
In vivo
In mice, IC87114 (15 mg/kg–60 mg/kg) inhibits the allergic response in the back skin and ear. In mice induced with anti-CD3 or ConA, IC87114 (30 mg/kg) reduces hypersensitivity responses and decreases plasma levels of cytokines, such as IL-2, IL-4, IL-17, IFN-γ, and tumor necrosis factor-α (TNF-α).
references
[1]. workman p, van montfort rl. pi(3) kinases: revealing the delta lady. nat chem biol. 2010 feb;6(2):82-3.[2]. puri kd, doggett ta, douangpanya j, hou y, tino wt, wilson t, graf t, clayton e, turner m, hayflick js, diacovo tg. mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. blood. 2004 may 1;103(9):3448-56. [3]. soond dr, bj?rgo e, moltu k, dale vq, patton dt, torgersen km, galleway f, twomey b, clark j, gaston js, taskén k, bunyard p, okkenhaug k. pi3k p110delta regulates t-cell cytokine production during primary and secondary immune responses in mice and humans. blood. 2010 mar 18;115(11):2203-13.
Check Digit Verification of cas no
The CAS Registry Mumber 371242-69-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,1,2,4 and 2 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 371242-69:
(8*3)+(7*7)+(6*1)+(5*2)+(4*4)+(3*2)+(2*6)+(1*9)=132
132 % 10 = 2
So 371242-69-2 is a valid CAS Registry Number.
InChI:InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)
