37111-25-4Relevant articles and documents
Regio- and chemoselective rearrangement of terminal epoxides into methyl alkyl and aryl ketones
Tian, Yingying,Jürgens, Eva,Kunz, Doris
supporting information, p. 11340 - 11343 (2018/10/31)
The development of the highly active pincer-type rhodium catalyst 2 for the nucleophilic Meinwald rearrangement of functionalised terminal epoxides into methyl ketones under mild conditions is presented. An excellent regio- and chemoselectivity is obtained for the first time for aryl oxiranes.
Role of the (Acyloxy)methyl Moiety in Eliciting the Adrenergic β-Blocking Activity of 3-(Acyloxy)propanolamines
Macchia, B.,Balsamo, A.,Lapucci, A.,Macchia, F.,Martinelli, A.,et al.
, p. 616 - 622 (2007/10/02)
Some totally aliphatic 3-(acyloxy)propanolamines were synthesized with the aim of testing whether β-blocking activity could be obtained from this class of drugs, even in the absence of an aromatic group.The significant and, in most cases, competitive β-blocking activity shown by the compounds under examination, together with the results of a theoretical study in which their reactivity was compared with that of other adrenergic β-blocking drugs, seems to confirm a hypothesis previously advanced on the basis of knowledge about the action mechanism of adrenergic β-blocking drugs and of the results of structural studies.It was also possible to suggest some considerations about the role played by the (acyloxy)methyl portion of 3-(acyloxy)propanolamines in eliciting their adrenergic β-blocking activity.
A Convenient Synthesis of Glycidyl Esters (2,3-Epoxypropyl Alkanoates)
Otera, Junzo,Matsuzaki, Shinjiro
, p. 1019 - 1020 (2007/10/02)
A novel method for synthesizing glycidyl esters (2,3-epoxypropyl alkanoates) 1 has been achieved by the sequence of the organotin phosphate catalyzed reaction of epichlorohydrin 2 with carboxylic acids and dehydrochlorination of the resulting mixture of ester chlorohydrins 3 + 4 followed by separation.