36941-00-1

Basic information

• Product Name: 1-Propanone, 1-(4-hydroxyphenyl)-3-phenyl-
• Synonyms: 4'-hydroxydihydrochalcone;1-(4-hydroxy-phenyl)-3-phenyl-propan-1-one;4'-hydroxy-3-phenylpropiophenone;1-(4-hydroxyphenyl)-3-phenylpropan-1-one;1-(4-Hydroxy-phenyl)-3-phenyl-propan-1-on
• CAS NO: 36941-00-1
• Molecular Formula: C15H14O2
• Molecular Weight: 226.275
• Mol File: 36941-00-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(4-hydroxyphenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(4-hydroxyphenyl)-3-phenyl-(36941-00-1)
• EPA Substance Registry System: 1-Propanone, 1-(4-hydroxyphenyl)-3-phenyl-(36941-00-1)

Safety Data

• Hazardous Substances Data: 36941-00-1(Hazardous Substances Data)

Usage

Physical form

White crystalline powder

Uses

Intermediate in the synthesis of various pharmaceuticals and organic compounds

Properties

Antioxidant, antiproliferative, and anti-inflammatory

Potential applications

Development of new drugs and treatments, neuroprotective and anti-aging agent

Additional uses

Production of fragrances and flavor compounds due to its sweet, floral aroma

Upstream product

• 726-26-1 phenyl 3-phenylpropanoate 
• 22966-19-4 trans-4'-methoxychalcone 
• 99-93-4 4-Hydroxyacetophenone 
• 100-51-6 benzyl alcohol 
• 2657-25-2 4'-hydroxychalcone 
• 104-53-0 3-phenyl-propionaldehyde 
• 106-48-9 4-chloro-phenol 
• 645-45-4 hydrocinnamic acid chloride 
• 108-95-2 phenol 
• 100-52-7 benzaldehyde 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 2657-25-2 (E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 5564-84-1 1-[4-(3-dimethylamino-propoxy)-phenyl]-3-phenyl-propan-1-one 
• 5739-38-8 1-(4-methoxyphenyl)-3-phenylpropan-1-one 
• 126266-84-0 6-(3-phenylpropionyl)-1,3-benzodioxane 
• 101329-38-8 C₁₅H₁₃BrO₂ 
• 134994-61-9 4'-[(6-(dimethylamino)hexyl)oxy]-3-phenylpropiophenone 
• 197915-32-5 3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-(4-hydroxy-phenyl)-6-phenethyl-5,6-dihydro-pyran-2-one 
• 719311-30-5 2-(2,5-dihydroxy-phenylsulfanyl)-3-phenyl-1-(4-triisopropylsilanyloxy-phenyl)-propan-1-one 
• 719311-06-5 2-bromo-3-phenyl-1-(4-triisopropylsilanyloxy-phenyl)-propan-1-one 
• 719310-84-6 3-phenyl-1-(4-triisopropylsilanyloxy-phenyl)-propan-1-one 
• 94914-57-5 1-[4-(2-dimethylamino-ethoxy)-phenyl]-3-phenyl-propan-1-one 
• 36115-40-9 1-(4-oxiranylmethoxy-phenyl)-3-phenyl-propan-1-one 
• 95465-75-1 4-acetyloxy-1-(β-phenyl)propionylbenzene 
• 104245-74-1 1-(4-octoxyphenyl)-3-phenylpropan-1-one 
• 98218-41-8 1-(4-pentoxyphenyl)-3-phenylpropan-1-one 

Relevant articles and documents

Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride

Under mild conditions (room temperature, 80 psi of H2) Cp*Rh(2-(2-pyridyl)phenyl)H catalyzes the selective hydrogenation of the C═C bond in α,β-unsaturated carbonyl compounds, including natural product precursors with bulky substituents in the β position and substrates possessing an array of additional functional groups. It also catalyzes the hydrogenation of many isolated double bonds. Mechanistic studies reveal that no radical intermediates are involved, and the catalyst appears to be homogeneous, thereby affording important complementarity to existing protocols for similar hydrogenation processes.

Methanol as hydrogen source: Chemoselective transfer hydrogenation of α,β-unsaturated ketones with a rhodacycle

Methanol is a safe, economic and easy-to-handle hydrogen source. It has rarely been used in transfer hydrogenation reactions, however. We herein report that a cyclometalated rhodium complex, rhodacycle, catalyzes highly chemoselective hydrogenation of α,β-unsaturated ketones with methanol as the hydrogen source. A wide variety of chalcones, styryl methyl ketones and vinyl methyl ketones, including sterically demanding ones, were reduced to the saturated ketones in refluxing methanol in a short reaction time, with no need for inter gas protection, and no reduction of the carbonyl moieties was observed. The catalysis described provides a practically easy and operationally safe method for the reduction of olefinic bonds in α,β-unsaturated ketone compounds.

Organocatalyzed biomimetic selective reduction of c=c double bonds of chalcones

In this article, we reported a biomimetic approach for chemoselective reduction of C=C double bonds in chalcones under metal and acid free conditions, that relies on olefin activation by hydrogen bond formation. The process requires only catalytic amount of ephedrine as hydrogen bond donor and utilizes Hantzsch esters for transfer hydrogenation.