3685-22-1

Basic information

• Product Name: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID
• Synonyms: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;CIS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;cis-4-Hydroxycyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4-hydroxy-, cis-;(1s,4s)-4-hydroxycyclohexanecarboxylic acid;RANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID;cis-4-Hydroxycyclohexanecarboxylic Acid
• CAS NO: 3685-22-1
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.17
• Product Categories: 4-Substituted Cyclohexanecarboxylic Acids
• Mol File: 3685-22-1.mol
• Article Data: 13

Chemical Properties

• Melting Point: 150°C
• Boiling Point: 307.898 °C at 760 mmHg
• Flash Point: 154.234 °C
• Appearance: /
• Density: 1.246
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• Solubility: almost transparency in Methanol
• PKA: pK1:4.836 (25°C)
• CAS DataBase Reference: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID(3685-22-1)
• EPA Substance Registry System: TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID(3685-22-1)

Safety Data

• Hazard Codes: T
• Statements: 36/37/38-25
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 3685-22-1(Hazardous Substances Data)

Usage

General Description

TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID is a chemical compound with the molecular formula C7H12O3. It is a cyclic carboxylic acid featuring a hydroxyl group and a carboxyl group in a trans configuration on a cyclohexane ring. TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID is used in organic synthesis and as a starting material for the preparation of various pharmaceuticals and agrochemicals. It is also used as a building block for the synthesis of a wide range of chemical compounds with potential applications in the fields of medicine, agriculture, and materials science. TRANS-4-HYDROXYCYCLOHEXANECARBOXYLIC ACID has a role in the production of certain drugs and can be used in the development of new molecules with biological activity.

InChI:InChI=1/C7H12O3/c8-6-3-1-5(2-4-6)7(9)10/h5-6,8H,1-4H2,(H,9,10)/t5-,6+

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 6940-58-5 pentane-1,3,5-tricarboxylic acid 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 3618-04-0 4-hydroxycyclohexyl carboxylic acid ethyl ester 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 75877-66-6 ethyl (1s,4s)-4-hydroxycyclohexanecarboxylate 
• 98-89-5 Cyclohexanecarboxylic acid 
• 64-19-7 acetic acid 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 4350-84-9 2-oxa-bicyclo[2.2.2]octan-3-one 
• 7732-18-5 water 

Downstream Products

• 3618-03-9 methyl cis-4-hydroxycyclohexanecarboxylate 
• 103260-78-2 cis-4-acetoxy-cyclohexanecarboxylic acid methyl ester 
• 27548-81-8 trans-4-acetoxy-cyclohexanecarboxylic acid 
• 204712-78-7 cis-4-acetoxy-cyclohexanecarboxylic acid 
• 1378808-36-6 C₁₀H₁₄O₄ 
• 3618-03-9 methyl 4-hydroxycyclohexanecarboxylate 
• 1028853-17-9 4-(4-Hydroxy-cyclohexanecarbonyl)-[1,4]diazepane-1-carboxylic acid (5-tert-butyl-isoxazol-3-yl)-amide 
• 874-61-3 4-oxocyclohexanecarboxylic acid 
• 1242558-74-2 C₁₄H₁₇F₂NO₃ 
• 1508263-14-6 C₅₈H₈₉NO₁₅ 
• 102437-33-2 (1S,3R,4R)-3-Allyl-4-formyl-cyclohexanecarboxylic acid methyl ester 
• 102437-33-2 (1R,3R,4R)-3-Allyl-4-formyl-cyclohexanecarboxylic acid methyl ester 
• 102437-33-2 (1S,3R)-3-Allyl-4-formyl-cyclohexanecarboxylic acid methyl ester 
• 102437-22-9 (1R,3R,4S)-4-Hydroxy-3-(3-hydroxy-propyl)-cyclohexanecarboxylic acid methyl ester 

Relevant articles and documents

PNO ligand containing planar chiral ferrocene and axial chiral diphenol and application thereof

The invention discloses a PNO ligand containing planar chiral ferrocene and axially chiral diphenol and application of the PNO ligand. The PNO ligand containing planar chiral ferrocene and axially chiral diphenol is shown in any one of general formulas (I)-(IV). Or a PNO ligand containing planar chiral ferrocene and axial chiral diphenol as shown in any one of general formulas (V)-(VIII); compared with a previously reported tridentate ligand, the PNO ligand containing the planar chiral ferrocene and the axial chiral diphenol not only has good stability and easiness in synthesis, but also has planar chirality and axial chirality and has a good chiral environment, so that not only is excellent selectivity to a substrate ensured, but also the catalytic activity of a catalyst and the application range of the substrate are further improved. The chiral raw materials used in the invention are commercial bulk products, and the ligand synthesis route is simpler, so that large-scale production can be well carried out, and the method has a huge commercial application prospect.

A Molecular Torsion Balance Study: A Nearby Anionic Group Exerts Little Influence on Hydrophobic Interactions between Nonpolar Surfaces

Polar groups have a solvent ordering effect on water and therefore may affect hydrophobic binding energies for nearby lipophilic surfaces. This would mean that determinations of excess surface free energy association energies require consideration of nearby polar functional groups. This paper reports results of a study to measure this possible effect. It was concluded from the models used here that an anionic polar group nearby a hydrophobic surface has little or no effect on the magnitude of hydrophobic association.

DOPAMINE D3 RECEPTOR ANTAGONISTS HAVING A BICYCLO MOIETY

The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.