368-22-9

Basic information

• Product Name: salicylaldehyde-(4-fluoro-phenylhydrazone)
• Synonyms: salicylaldehyde-(4-fluoro-phenylhydrazone)
• CAS NO: 368-22-9
• Molecular Weight: 230.242
• Mol File: 368-22-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: salicylaldehyde-(4-fluoro-phenylhydrazone)(CAS DataBase Reference)
• NIST Chemistry Reference: salicylaldehyde-(4-fluoro-phenylhydrazone)(368-22-9)
• EPA Substance Registry System: salicylaldehyde-(4-fluoro-phenylhydrazone)(368-22-9)

Safety Data

• Hazardous Substances Data: 368-22-9(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 371-14-2 4-fluorophenylhydrazine 

Relevant articles and documents

Synthesis and anti-HIV-1 activity evaluation for novel 3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione derivatives

The search for new molecular constructs that resemble the critical two-metal binding pharmacophore and the halo-substituted phenyl functionality required for HIV-1 integrase (IN) inhibition represents a vibrant area of research within drug discovery. As reported herein, we have modified our recently disclosed 1-[2-(4-fluorophenyl)ethyl]-pyrrole-2,5-dione scaffolds to design 35 novel compounds with improved biological activities against HIV-1. These new compounds show single-digit micromolar antiviral potencies against HIV-1 and low toxicity. Among of them, compound 9g and 15i had potent anti-HIV-1 activities (EC50 50 /EC50 > 100). These two compounds have potential as lead compounds for further optimization into clinical anti-HIV-1 agents.