3663-34-1

Basic information

• Product Name: N-(4-ethylphenyl)acetamide
• Synonyms: N-(4-ethylphenyl)acetamide
• CAS NO: 3663-34-1
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• EINECS: -0
• Mol File: 3663-34-1.mol
• Article Data: 43

Chemical Properties

• Boiling Point: 324.2°Cat760mmHg
• Flash Point: 189.8°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.00025mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: N-(4-ethylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-ethylphenyl)acetamide(3663-34-1)
• EPA Substance Registry System: N-(4-ethylphenyl)acetamide(3663-34-1)

Safety Data

• Hazardous Substances Data: 3663-34-1(Hazardous Substances Data)

Usage

General Description

N-(4-ethylphenyl)acetamide, also known as 4-ethylacetanilide, is an organic compound with the chemical formula C10H13NO. It is a derivative of acetanilide and is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and pesticides. N-(4-ethylphenyl)acetamide is a white solid at room temperature and is soluble in most organic solvents. N-(4-ethylphenyl)acetamide is primarily used as a precursor in the production of various pharmaceutical drugs, particularly analgesics and antipyretics. It is also employed in the synthesis of herbicides and other agricultural chemicals. Due to its versatile applications, this chemical is an important building block in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H13NO/c1-3-9-4-6-10(7-5-9)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)

Upstream product

• 1220120-57-9 tert-butyl N-(p-ethylphenyl)carbamate 
• 75-36-5 acetyl chloride 
• 563-63-3 silver(I) acetate 
• 143063-89-2 para-ethylphenyl isocyanide 
• 64-19-7 acetic acid 
• 127-08-2 potassium acetate 
• 123-54-6 acetylacetone 
• 589-16-2 4-aminoethylbenzene 
• 4218-48-8 1-ethyl-4-isopropylbenzene 
• 141-78-6 ethyl acetate 
• 14235-81-5 4-Ethynylaniline 
• 22955-65-3 1-ethyl-4-nitrosobenzene 
• 431-03-8 dimethylglyoxal 
• 2719-21-3 4-(N-acetylamino)acetophenone 

Downstream Products

• 2725-82-8 1-bromo-3-ethylbenzene 
• 90868-93-2 N-(2-bromo-4-ethylphenyl)acetamide 
• 3663-33-0 acetic acid-(4-ethyl-2-nitro-anilide) 
• 29452-10-6 4-ethylthioacetanilide 
• 111630-95-6 acetic acid-(4-ethyl-2,6-dinitro-anilide) 
• 38678-86-3 2-bromine-4-ethylaniline 
• 338428-47-0 6-ethyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde 
• 53498-47-8 N-(4-vinyl-phenyl)-acetamide 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 436088-07-2 2-chloro-6-ethyl-3-formylquinoline 

Relevant articles and documents

Determination of Alkyl Anilines and Alkyl Pyridines in Solvent Refined Coal Distillates and Aqueous Extracts by Gas Chromatography/Mass Spectrometry

Derivatization with acetic anhydride in aqueous media coupled with capillary gas chromatography/mass spectrometry was used to distinguish alkyl anilines from alkyl pyridines.By use of this approach aniline, C-1 anilines, and C-2 anilines, as well as lesse

Method for promoting acylation of amine or alcohol by carbon dioxide

The invention relates to a method for promoting acylation of amine or alcohol by carbon dioxide, which comprises the following steps of: mixing an amine compound, carboxylate or thiocarboxylate compound and a reaction solvent under the action of carbon dioxide, and reacting to obtain an amide compound, or under the action of carbon dioxide, mixing the alcohol compound, the thiocarboxylate compound and the reaction solvent [gamma]-valerolactone, and reacting to obtain the ester compound. According to the invention, under the promotion action of carbon dioxide, carboxylate or thiocarboxylate is used as an acylation reagent, and amine and alcohol are converted into amide and ester compounds in the absence of a transition metal catalyst, so that acylation reagents such as acyl chloride or anhydride with irritation and corrosivity are avoided; and the method has the advantages of simple operation, mild reaction conditions, high tolerance of substrate functional groups, strong applicability and high yield, and provides an efficient, reliable and economical preparation method for synthesis of amide and ester compounds.

Catalyst-free generation of acyl radicals induced by visible light in water to construct C-N bonds

We describe herein a catalyst-free and redox-neutral photochemical strategy for the direct generation of acyl radicals from α-diketones, and its selective conversion of nitrosoarenes to hydroxyamides or amides with AcOH or NaCl as an additive. The reaction was carried out under mild conditions in water with purple LEDs as the light source. A broad scope of substrates was demonstrated. Mechanistic experiments indicate that α-diketones cleave to give acyl radicals, with hydroxyamides being further reduced to amides.