36414-00-3

Basic information

• Product Name: 7-[[(2E)-5-(3,3-Dimethyl-2-oxiranyl)-3-methyl-2-penten-1-yl]oxy]-2H-1-benzopyran-2-one
• Synonyms: (+/-)-Epoxyaurapten;6',7'-Epoxy-7-geranyloxycoumarin;7-[[(2E)-5-(3,3-Dimethyl-2-oxiranyl)-3-methyl-2-penten-1-yl]oxy]-2H-1-benzopyran-2-one;Epoxyauraptene
• CAS NO: 36414-00-3
• Molecular Formula: C₁₉H₂₂O₄
• Molecular Weight: 314.37558
• Mol File: 36414-00-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.140
• CAS DataBase Reference: 7-[[(2E)-5-(3,3-Dimethyl-2-oxiranyl)-3-methyl-2-penten-1-yl]oxy]-2H-1-benzopyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-[[(2E)-5-(3,3-Dimethyl-2-oxiranyl)-3-methyl-2-penten-1-yl]oxy]-2H-1-benzopyran-2-one(36414-00-3)
• EPA Substance Registry System: 7-[[(2E)-5-(3,3-Dimethyl-2-oxiranyl)-3-methyl-2-penten-1-yl]oxy]-2H-1-benzopyran-2-one(36414-00-3)

Safety Data

• Hazardous Substances Data: 36414-00-3(Hazardous Substances Data)

Upstream product

• 5389-87-7 1-chloro-3,7-dimethylocta-2,6-diene 

Downstream Products

• 5980-09-6 (6'R,2'E)-dihydroxy-6',7' dimethyl-3',7' octene-2' oxy-7 coumarine 
• 118628-99-2 (S)-7-[5-(3,3-dimethyloxiranyl)-3-methylpent-2E-enyloxy]chromen-2-one 
• 21499-17-2 Epoxyaurapten 
• 98066-12-7 (+/-)-(E)-7-<<(3-tetrahydro-5,5-dimethyl-4-oxo-2-furanyl)-2-butenyl>-oxy>-2H-1-benzopyran-2-one 
• 36413-91-9 geiparvarin 
• 118584-16-0 7-(5-hydroxy-2,6,6-trimethyl-cyclohex-2-enylmethoxy)-chromen-2-one 
• 21499-19-4 7-((1S,2S,4R)-1,3,3-Trimethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethoxy)-chromen-2-one 
• 32064-14-5 7-((E)-7-Chloro-6-hydroxy-3,7-dimethyl-oct-2-enyloxy)-chromen-2-one 
• 31947-01-0 7-((S)-3-Hydroxy-2,2-dimethyl-6-methylene-cyclohexylmethoxy)-chromen-2-one 
• 36413-96-4 7-(7-hydroxy-3,7-dimethyl-6-oxooct-2E-enyloxy)chromen-2-one 

Relevant articles and documents

Identification and biological evaluation of grapefruit oil components as potential novel efflux pump modulators in methicillin-resistant Staphylococcus aureus bacterial strains

Grapefruit oil components were isolated and characterised and evaluated for intrinsic antibacterial activity and modulating effect in MRSA and MSSA strains. The grapefruit component 4-{[(E)-5-(3,3-dimethyl-2-oxiranyl)-3-methyl- 2-pentenyl]oxy}-7H-furo[3,2-g]chromen-7-one (2) enhanced the susceptibility of MRSA bacteria strains and other micro-organisms to agents, e.g. ethidium bromide and norfloxacin, to which these micro-organisms are normally resistant. Methicillin-resistant Staphylococcus aureus (MRSA) and MSSA strains were treated with: (a) grapefruit oil (GFO) components, isolated by chromatography and characterised by NMR and mass spectroscopy; (b) antimicrobial agents, or (c) a combination of both to evaluate (MIC determination) intrinsic antibacterial activity and to determine whether GFO components could modulate bacterial sensitivity to the anti-bacterial agents. Preliminary data suggested that the grapefruit component 4-{[(E)-5-(3,3-dimethyl-2-oxiranyl)-3-methyl-2-pentenyl] oxy}-7H-furo[3,2-g]chromen-7-one (2) enhances the susceptibility of test MRSA strains to agents, e.g., ethidium bromide and norfloxacin, to which these micro-organisms are normally resistant.