36304-81-1

Basic information

• Product Name: dimemorphan
• Synonyms: dimemorphan;Morphinan, 3,17-dimethyl-, (+-)- (9CI)
• CAS NO: 36304-81-1
• Molecular Formula: C18H25 N
• Molecular Weight: 0
• Mol File: 36304-81-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: dimemorphan(CAS DataBase Reference)
• NIST Chemistry Reference: dimemorphan(36304-81-1)
• EPA Substance Registry System: dimemorphan(36304-81-1)

Safety Data

• Hazardous Substances Data: 36304-81-1(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 1078151-90-2 C₂₅H₂₉NO₂ 
• 36309-11-2 (+)-1-p-methylbenzyl-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline 
• 38973-16-9 2-methyl-1-(4-methyl-benzyl)-1,2,3,4,5,6,7,8-octahydro-isoquinoline 
• 75-16-1 methylmagnesium bromide 
• 125-71-3 dextromethorphan 
• 1216910-39-2 (+)-17-ethylcarbamate-3-methyl-(9α,13α,14α)-morphinan 
• 1216910-34-7 (4bS,8aS,9S)-ethyl 3-(((trifluoromethyl)sulfonyl)oxy)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)-phenanthrene-11-carboxylate 
• 524713-55-1 (4bS,8aS,9S)-ethyl 3-methoxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate 
• 1079043-47-2 (4bS,8aS,9S)-ethyl 3-hydroxy-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano)phenanthrene-11-carboxylate 

Downstream Products

• 36304-84-4 Dimemorfan phosphate 

Relevant articles and documents

Method for preparing high-purity dimemorfan

The invention relates to the technical field of drug synthesis, and particularly relates to a method for preparing a key intermediate dimemorfan of a nonaddictive central antitussive dimemorfan phosphate. The method is characterized by comprising the following steps in sequence: using (S)-1-(4-methylbenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline-L-mandelate as a starting raw material, and adding analkali to neutralize for removing mandelic acid; afterwards, adding a formylation reagent to obtain an intermediate (S)-1-(4-methylbenzyl)-N-formyl-1,2,3,4,5,6,7,8-octahydroisoquinoline; afterwards,adding a cyclization reagent to carry out a cyclization reaction, so a to obtain an intermediate 3-methyl-17-formyldextromethorphan; afterwards, carrying out a reduction reaction or hydrolyzing, and then carrying out a methylation reaction, so that dimemorfan is obtained. The method provided by the invention is not only short in preparation cycle, but also, more importantly, is used for greatly improving a product yield, and the impurity content is obviously reduced.

An efficient synthesis of dimemorfan from dextromethorphan

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Opioid and opioid-like compounds and uses thereof

The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage.