3615-44-9 Usage
Description
D-Mannoheptulose is a naturally occurring heptose that functions as a competitive inhibitor of glucokinases and hexokinases, which are enzymes responsible for phosphorylating D-glucose to produce glucose-6-phosphate in humans. By competing with D-glucose, D-mannoheptulose effectively blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. This action prevents the conversion of glucose to glucose-6-phosphate, which is essential for the activation of the carbohydrate response element binding protein. As a result, D-mannoheptulose can cause transient hyperglycemia in dogs at higher doses but not at lower doses, while also increasing postprandial energy expenditure.
Used in Pharmaceutical Industry:
D-Mannoheptulose is used as a pharmaceutical agent for normalizing insulin levels and reducing weight. Its ability to inhibit glucose phosphorylation and modulate insulin release makes it a potential candidate for the treatment of conditions related to glucose metabolism and insulin resistance.
Used in Nutritional Supplements:
D-Mannoheptulose is used as a nutritional supplement to support healthy glucose metabolism and weight management. Its presence in avocado fruit suggests that it may have a role in promoting overall health and well-being.
Used in Research Applications:
D-Mannoheptulose is used as a research tool to study the mechanisms of glucose metabolism, insulin release, and the role of glucokinases and hexokinases in various organisms. This knowledge can contribute to the development of new therapeutic strategies for managing glucose-related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 3615-44-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,1 and 5 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 3615-44:
(6*3)+(5*6)+(4*1)+(3*5)+(2*4)+(1*4)=79
79 % 10 = 9
So 3615-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H14O7/c8-1-3-4(10)5(11)6(12)7(13,2-9)14-3/h3-6,8-13H,1-2H2/t3?,4-,5-,6?,7?/m1/s1
