361147-55-9

Basic information

• Product Name: 4-hydroxy-2,3-dimethoxy-4-(4-phenyl-but-1-ynyl)-cyclobut-2-enone
• Synonyms: 4-hydroxy-2,3-dimethoxy-4-(4-phenyl-but-1-ynyl)-cyclobut-2-enone
• CAS NO: 361147-55-9
• Molecular Weight: 272.301
• Mol File: 361147-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-2,3-dimethoxy-4-(4-phenyl-but-1-ynyl)-cyclobut-2-enone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-2,3-dimethoxy-4-(4-phenyl-but-1-ynyl)-cyclobut-2-enone(361147-55-9)
• EPA Substance Registry System: 4-hydroxy-2,3-dimethoxy-4-(4-phenyl-but-1-ynyl)-cyclobut-2-enone(361147-55-9)

Safety Data

• Hazardous Substances Data: 361147-55-9(Hazardous Substances Data)

Upstream product

• 16520-62-0 4-Phenyl-1-butyne 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 

Downstream Products

• 361147-57-1 2-((E)-1-Bromo-3-phenyl-allylidene)-4,5-dimethoxy-cyclopent-4-ene-1,3-dione 
• 3984-73-4 Methyllinderone 
• 361147-56-0 2-(1-bromo-3-phenyl-propylidene)-4,5-dimethoxy-cyclopent-4-ene-1,3-dione 

Relevant articles and documents

Total synthesis of human chymase inhibitor methyllinderone and structure - Activity relationships of its derivatives

Total synthesis of human chymase inhibitor methyllinderone has been achieved in only four steps with an overall yield of 21% from dimethyl squarate. We developed an efficient synthetic method for obtaining methyllinderone derivatives and found the active compound. In addition, we propose the inhibition mechanism of the active compound against human chymase using calculations.